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The severity of COVID\u201019 varies, ranging from asymptomatic cases to mild symptoms, acute respiratory failure and death. Genetic factors are believed to influence individual responses to the virus. This study investigates the association between two common single nucleotide polymorphisms (SNPs) in Toll\u2010like receptors (TLRs)\u2014<jats:italic>TLR2<\/jats:italic> rs3804099 (+597 C\/T) and <jats:italic>TLR4<\/jats:italic> rs4986790 (+896 A\/G)\u2014and disease severity and inflammatory markers in Moroccan COVID\u201019 patients. A total of 452 COVID\u201019 patients (259 with mild\/moderate disease and 193 with severe disease) were included. <jats:italic>TLR2<\/jats:italic> and <jats:italic>TLR4<\/jats:italic> SNPs were genotyped using a predesigned TaqMan real\u2010time allelic discrimination assay. Complete blood count samples, along with levels of C\u2010reactive protein (CRP), ferritin, procalcitonin and D\u2010dimer, were assessed using automated methods. No significant associations were observed between either SNP in <jats:italic>TLR2<\/jats:italic> and <jats:italic>TLR4<\/jats:italic> and disease severity under various genetic models. However, in severe cases, <jats:italic>TLR4<\/jats:italic> rs4986790 showed a significant association with ferritin levels (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0002) and lymphocyte count (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). <jats:italic>TLR2<\/jats:italic> rs3804099 was linked to CRP levels in severe patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036). No associations were observed with anti\u2010receptor\u2010binding domain (RBD) IgG or anti\u2010N IgG levels in severe cases (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). These findings suggest that although <jats:italic>TLR4<\/jats:italic> and <jats:italic>TLR2<\/jats:italic> polymorphisms are not directly associated with COVID\u201019 severity, they may influence the inflammatory response. Specifically, <jats:italic>TLR4<\/jats:italic> rs4986790 and <jats:italic>TLR2<\/jats:italic> rs3804099 appear to modulate ferritin and CRP levels, potentially impacting disease progression in severe cases.<\/jats:p>","DOI":"10.1111\/iji.70002","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T01:33:07Z","timestamp":1749346387000},"page":"213-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Variations in <i>TLR2<\/i> and <i>TLR4<\/i> Genes and Their Association With COVID\u201019 Severity and Inflammatory Markers in the Moroccan Population"],"prefix":"10.1111","volume":"52","author":[{"given":"Rachid","family":"Noureddine","sequence":"first","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"},{"name":"Laboratory of Genetics and Molecular Pathology Medical School University Hassan II  Casablanca Morocco"},{"name":"Laboratoire Morizgo d'Analyses M\u00e9dicales  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Haddaji","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie de La\u00e2youne Ibn Zohr University  Laayoune Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u00e2","family":"Baba","sequence":"additional","affiliation":[{"name":"Biotechnology R&amp;D Unit Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahd","family":"Ouladlahsen","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses CHU Ibn Rochd  Casablanca Morocco"},{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Hassan II University  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safaa","family":"Aqillouch","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumaima","family":"Laazaazia","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achraf","family":"Aainouss","sequence":"additional","affiliation":[{"name":"Laboratoire Morizgo d'Analyses M\u00e9dicales  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind","family":"Dehbi","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Pathology Medical School University Hassan II  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayeh","family":"Ezzikouri","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO The Current COVID\u201019 Situation. 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