{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T11:02:50Z","timestamp":1762599770388,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Background: Acute lymphoblastic leukaemia (ALL) is characterized by the clonal proliferation of immature lymphoid precursors in the bone marrow or peripheral blood. This study investigates whether genetic polymorphisms in\n                    <jats:italic>IL\u201017RC<\/jats:italic>\n                    are associated with an increased risk of ALL in the Saudi population.\n                  <\/jats:p>\n                  <jats:p>\n                    Methods: This case\u2010control study included 95 patients with ALL and 95 matched controls. Genetic polymorphisms and their associations with ALL risk were identified using logistic regression analysis. Additionally, quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) was used to assess the level of\n                    <jats:italic>IL\u201017RC<\/jats:italic>\n                    mRNA.\n                  <\/jats:p>\n                  <jats:p>\n                    Results: The results revealed that carriers of the GA and AA genotypes of rs76999397 had a significantly increased risk of ALL (GA: odds ratios [OR]\u00a0=\u00a063.78, 95% confidence interval [CI]\u00a0=\u00a025.51\u2013159.43,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001; AA: OR\u00a0=\u00a018.22, 95% CI\u00a0=\u00a01.50\u2013221.37,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001). Additionally, we identified that an increased risk of ALL was associated with two haplotypes in\n                    <jats:italic>IL\u201017RC<\/jats:italic>\n                    , C\u2010A and T\u2010A (in the order of rs708567 and rs76999397) (OR\u00a0=\u00a046.73, 95% CI\u00a0=\u00a017.30\u2013126.28; OR\u00a0=\u00a049.42, 95% CI\u00a0=\u00a06.95\u2013351.45, respectively).\n                  <\/jats:p>\n                  <jats:p>Conclusions: The results suggested that the GA and AA genotypes of rs76999397 were significantly associated with an increased risk of ALL, whereas rs708567 did not show a significant association. Furthermore, the CA and TA haplotypes (rs708567\/rs76999397) were found to be associated with increased susceptibility to ALL.<\/jats:p>","DOI":"10.1111\/iji.70012","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T06:24:40Z","timestamp":1756707880000},"page":"352-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of IL\u201017RC Polymorphisms rs708567 and rs76999397 With Acute Lymphoblastic Leukaemia"],"prefix":"10.1111","volume":"52","author":[{"given":"Ali","family":"Aljuaimlani","sequence":"first","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamjed","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jameel","family":"Al\u2010Tamimi","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamilah","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa A.","family":"Alqarzae","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadwa M.","family":"Alkhulaifi","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suliman","family":"Alomar","sequence":"additional","affiliation":[{"name":"Department of Zoology College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.103460"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194883"},{"key":"e_1_2_9_4_1","unstructured":"Dormans J. S.Grant N.Rendon et\u00a0al.2010. \u201cA Genome Wide Association Study Identifies an IL17RC Missense Mutation (S111 L) as an Adolescent Idiopathic Scoliosis Locus.\u201d In60th Annual Meeting of the American Society of Human Genetics Washington DC: Platform Session 51: Polygenic Traits. GWAS Methods and Results 99.ASHG."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01558"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.02.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0185-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-04996-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62187-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.999407"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12173"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15104"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33018-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2021.06.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-02011-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq571"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl268"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.03.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.974"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.36"},{"key":"e_1_2_9_22_1","first-page":"1","article-title":"Association of IL17RC and COL6A1 Genetic Polymorphisms With Susceptibility to Ossification of the Thoracic Posterior Longitudinal Ligament in Chinese Patients","volume":"13","author":"Wang P.","year":"2018","journal-title":"Journal of Orthopaedic Surgery and Research"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-181"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.12659\/MSM.901494","article-title":"TS Gene Polymorphisms Correlate With Susceptibility to Acute Lymphocytic Leukemia in Children","volume":"23","author":"Zou R.","year":"2017","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.70012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:59:10Z","timestamp":1762599550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.70012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/iji.70012"],"URL":"https:\/\/doi.org\/10.1111\/iji.70012","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"type":"print","value":"1744-3121"},{"type":"electronic","value":"1744-313X"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"assertion":[{"value":"2024-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}