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Genetic variants of\n                    <jats:italic>TLRs<\/jats:italic>\n                    are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in\n                    <jats:italic>TLR1, TLR4, TLR7, TLR8, TLR9<\/jats:italic>\n                    and\n                    <jats:italic>TIRAP<\/jats:italic>\n                    and the clinical manifestations of malaria caused by\n                    <jats:italic>P. vivax<\/jats:italic>\n                    in a population from the Amazon region of Par\u00e1, Brazil. A total of 148 individuals with symptomatic uncomplicated malaria were genotyped for rs4833095, rs1927911, rs179008, rs3764880, rs352140 and rs8177374 variants, and their associations with parasitaemia levels, gametocytaemia and clinical index were analysed using generalised linear models.\n                    <jats:italic>TLR9<\/jats:italic>\n                    rs352140TT homozygotes had higher parasitaemia levels than C allele carriers (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.034).\n                    <jats:italic>TLR4<\/jats:italic>\n                    rs1927911GG homozygotes had a higher clinical index than A allele carriers (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.018). Our results describe, for the first time, the association of the rs1927911 variant found in intron 1 of\n                    <jats:italic>TLR4<\/jats:italic>\n                    with\n                    <jats:italic>P. vivax<\/jats:italic>\n                    malaria symptoms in Brazilian Amazonian population.\n                  <\/jats:p>","DOI":"10.1111\/iji.70014","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T08:28:04Z","timestamp":1758184084000},"page":"371-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Evidence of\n                    <i>TLR4<\/i>\n                    and\n                    <i>TLR9<\/i>\n                    Variants Influencing Parasitaemia and Symptoms of\n                    <i>Plasmodium vivax<\/i>\n                    Infection"],"prefix":"10.1111","volume":"52","author":[{"given":"Mikaele Monik Rodrigues 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