{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:28:06Z","timestamp":1788996486098,"version":"build-2803163510"},"reference-count":158,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Over the years, accumulating evidence has been associating interleukin\u201013 gene (\n                    <jats:italic>IL\u201013<\/jats:italic>\n                    ) variants with a wide array of chronic inflammatory diseases. Also, recent findings have associated the potential role of a single nucleotide polymorphism (SNP) of IL\u201013, rs20541, to promote either anti\u2010 or pro\u2010inflammatory responses in chronic inflammatory diseases. Although rs20541 has been widely associated with various immune\u2010related and inflammatory conditions, its precise functional relevance in the pathogenesis of human diseases has yet to be fully clarified. Nonetheless, its consistent associations and known effects on IL\u201013 signalling underscore its potential biological importance. Hence, this meta\u2010analysis aimed to investigate the associations between IL\u201013 SNP rs20541 with distinct groups of chronic inflammatory diseases. Eligible studies were selected from seven databases including PubMed, EBSCO Host (all databases), Medline, CINAHL Plus, Scopus, SNPedia and GWAS. In total, 45 case\u2013control studies with 16,045 cases and 23,312 controls were categorised into four major groups: atopic, cardiopulmonary and autoimmune diseases as well as cancer and tumour. While no consistent associations emerged for asthma or overall atopic and cardiopulmonary groups, protective associations for psoriasis and glioma were observed across multiple genetic contrasts. The A allele of rs20541 was significantly associated with higher risk of chronic obstructive pulmonary diseases (COPDs) [1.17 (1.03\u20131.32)] but reduced risk of cardiovascular diseases (CVDs) [0.87 (0.75\u20131.00)], psoriasis [allele model: 0.71 (0.65\u20130.77); dominant model: 0.69 (0.62\u20130.76)], overall cancer [allele model: 0.82 (0.66\u20130.98); dominant model: 0.82 (0.67\u20130.98) and glioma [allele model: 0.82 (0.68\u20130.95); dominant model: 0.72 (0.57\u20130.87)]. In subgroup analysis and meta\u2010regression, sources of between\u2010study heterogeneity were associated with ethnicity, age, gender and sample size in respective disease groups (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>z<\/jats:sub>\n                    &lt; 0.05,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>res<\/jats:sub>\n                    &gt; 0.05). Overall, this meta\u2010analysis demonstrates that IL\u201013 rs20541 is a key immunogenetic variant exerting context\u2010dependent effects, either via direct lgE\u2010dependent or indirect regulatory effects across chronic inflammatory diseases. These mechanistic differences help explain why rs20541 confers susceptibility in some diseases while providing protection in others, reflecting the pleiotropic and tissue\u2010specific functions of IL\u201013. Future research should integrate transcriptional studies and eQTL analyses of rs20541 to clarify its downstream impact on inflammation\u2010specific genes, ultimately informing cytokine\u2010targeted therapies to more precisely manage and prevent chronic inflammatory disease.\n                  <\/jats:p>","DOI":"10.1111\/iji.70018","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T05:19:22Z","timestamp":1759295962000},"page":"313-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of IL\n                    <i>\u201013<\/i>\n                    Gene Polymorphism (rs20541) With Chronic Inflammatory Diseases: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Geetha","family":"Letchumanan","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences Sunway University  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010How","family":"Say","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences Sunway University  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.02.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00538-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14318"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"196","article-title":"Lack of Association Between Interleukin 13, Interleukin 4 Receptor Alpha, and ms4a2 Gene Polymorphisms and Asthma in Adult Saudis","volume":"3","author":"Al Abdulsalam E. A.","year":"2020","journal-title":"Journal of Nature and Science of Medicine"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/18743129-v17-e230714-2023-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.26577\/ijbch.2022.v15.i2.04"},{"issue":"6","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.reumae.2012.07.003","article-title":"Analysis of the rs20541 (R130Q) Polymorphism in the IL\u201013 Gene in Patients With Elderly\u2010Associated Chronic Inflammatory Diseases","volume":"8","author":"Alvarez\u2010Rodr\u00edguez L.","year":"2012","journal-title":"Reumatolog\u00eda Cl\u00ednica"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10050273"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.033"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124656"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.406"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201112-2142OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01020.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02167.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13954"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24245"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314366"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110235"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2132"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11282"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/bio.2015.29031.hmm"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330900"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05279-x"},{"issue":"7","key":"e_1_2_8_29_1","first-page":"6384","article-title":"IL\u201013 Polymorphisms rs20541 and rs1800925 in Atopic Dermatitis: A Meta\u2010Analysis","volume":"11","author":"Chen J.\u2010G.","year":"2018","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35447"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089519"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1334-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2024.2361594"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00802"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.31450\/ukrjnd.3(83).2024.06"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.07.018"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009990"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3512-z"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.169"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.2183"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3611"},{"key":"e_1_2_8_42_1","unstructured":"EMBL\u2010EBI (European Molecular Biology Laboratory\u2010 European Bioinformatics Institute).2025. \u201cGWAS Catalog Variant: rs20541.\u201dhttps:\/\/www.ebi.ac.uk\/gwas\/variants\/rs20541."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005014"},{"key":"e_1_2_8_44_1","unstructured":"Fernandez J.2024a. \u201cOverview of Allergic and Atopic Disorders MSD Manual Professional Edition: MSD Manual.\u201d Accessed August 2024.https:\/\/www.msdmanuals.com\/professional\/immunology\u2010allergic\u2010disorders\/allergic\u2010autoimmune\u2010and\u2010other\u2010hypersensitivity\u2010disorders\/overview\u2010of\u2010allergic\u2010and\u2010atopic\u2010disorders."},{"key":"e_1_2_8_45_1","unstructured":"Fernandez J.2024b. \u201cAutoimmune Disorders MSD Manual Professional Edition: MSD Manual.\u201d Accessed August 2024.https:\/\/www.msdmanuals.com\/professional\/immunology\u2010allergic\u2010disorders\/allergic\u2010autoimmune\u2010and\u2010other\u2010hypersensitivity\u2010disorders\/autoimmune\u2010disorders."},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01960"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07204"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4624"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/jor3020007"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154799"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519852092"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.20130225"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.007"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-49615-y"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-5-64"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12799"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211007687"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S373098"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.12.020"},{"key":"e_1_2_8_61_1","unstructured":"Harikrishnan S. P.Jeemon G.Mini K.Thankappan andP.Sylaja GBD 2017 Causes of Death Collaborators.2018.Global Regional and National Age\u2010Sex\u2010Specific Mortality for 282 Causes of Death in 195 Countries and Territories 1980\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017."},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp001"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.6.1832"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/413465"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.001020"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2015.04.003"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13081478"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307321110"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-4-9"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2021.1431"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-236"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15124"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-24-448"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08825-1"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005374"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.90"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3489"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13340"},{"issue":"6","key":"e_1_2_8_79_1","first-page":"691","article-title":"Mast Cell Chymase: An Indispensable Instrument in the Pathological Symphony of Idiopathic Pulmonary Fibrosis?","volume":"28","author":"Kosanovic D.","year":"2013","journal-title":"Histology and Histopathology"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1515\/bjmg-2016-0036"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052442"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.04.023"},{"key":"e_1_2_8_83_1","doi-asserted-by":"crossref","unstructured":"Letchumanan G. andS. Y.How.2024. \u201cAssociation of IL\u201013 Gene Polymorphism rs20541 (R130Q) With Inflammatory Diseases: A Systematic Review and Meta\u2010Analysis PROSPERO.\u201dhttps:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42024519477.","DOI":"10.1111\/iji.70018"},{"issue":"7","key":"e_1_2_8_84_1","article-title":"Race and Ethnic Categories: A Brief Review of Global Terms and Nomenclature","volume":"15","author":"Lewis C.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1307588"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.04.041"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12683"},{"issue":"1","key":"e_1_2_8_88_1","first-page":"708","article-title":"The rs20541 G>A Polymorphism in the Interleukin 13 Gene Is Associated With a Decreased Risk of Renal Cell Carcinoma in a Chinese Population","volume":"10","author":"Liang G.","year":"2017","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008556"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31537"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520929179"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2023.69.8.13"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.107935"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2010.02.001"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027363"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912629107"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205047200"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn075"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1354"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2019.100392"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-143"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-12-142"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci6020018"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.311"},{"key":"e_1_2_8_106_1","unstructured":"National Centre for Biotechnology Information (NCBI).2024. \u201crs20541 RefSNP Report.\u201dhttps:\/\/www.ncbi.nlm.nih.gov\/snp\/rs20541."},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.180"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2007.12.007"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2016.03.003"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15449"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.575181"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.218"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076061"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16566"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.11.037"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppnen.2016.06.009"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102925"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475415616073"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2565"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22091"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3728"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.035"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1556\/030.62.2015.4.2"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12313"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.12609"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.32364\/2587-6821-2021-5-1-32-37"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_56_18"},{"key":"e_1_2_8_128_1","volume-title":"Stata Statistical Software: Release 18","author":"StataCorp","year":"2023"},{"issue":"1","key":"e_1_2_8_129_1","first-page":"37","article-title":"Chronic Inflammatory Systemic Diseases: An Evolutionary Trade\u2010Off Between Acutely Beneficial but Chronically Harmful Programs","volume":"2016","author":"Straub R. H.","year":"2016","journal-title":"Evolution, Medicine, and Public Health"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.11.035"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.01.003"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.026"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2020.1832113"},{"issue":"1","key":"e_1_2_8_134_1","first-page":"1","article-title":"Genetic Association Between Selected Cytokine Genes and Glioblastoma in the Han Chinese Population","volume":"13","author":"Tianbo J.","year":"2013","journal-title":"BMC Cancer"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.01.009"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5346-x"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20114"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.04.082"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02453.x"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2257"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201204-0596PP"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3066"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12395"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.09.034"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.11.020"},{"key":"e_1_2_8_147_1","unstructured":"Wells G. A. B.Shea D.O'Connell et\u00a0al. \u201cThe Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses.\u201d2000."},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2014.44015"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0041"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1.51.pe55"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16672"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102193"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.899923"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480518"},{"key":"e_1_2_8_155_1","first-page":"107923","volume-title":"Impact of IL13 Genetic Polymorphisms on COPD Susceptibility in the Chinese Han Population. Respiratory Medicine","author":"Yang Z.","year":"2024"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24592-9"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078151"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_470_2023"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.24075\/brsmu.2019.067"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:58:54Z","timestamp":1762599534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":158,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/iji.70018"],"URL":"https:\/\/doi.org\/10.1111\/iji.70018","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}