{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:05:25Z","timestamp":1790715925852,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>COVID\u201019, caused by the SARS\u2010CoV\u20102 virus, manifests with varying degrees of severity, affecting individuals worldwide. The spectrum of symptoms ranges from mild to severe, with respiratory failure being a leading cause of death. Immunological factors, particularly excessive cytokine production such as IL\u201018 and IL\u20101\u03b2, significantly contribute to disease severity. In this context, the NLRP3 inflammasome, a key component of the innate immune system, has influenced COVID\u201019 outcomes. This study investigated the association between single\u2010nucleotide variants (SNVs) in the NLRP3 inflammasome and COVID\u201019 severity. A case\u2013control study was conducted involving 800 adult participants infected with SARS\u2010CoV\u20102, stratified into mild\/moderate and severe\/critical cases. Genetic associations were assessed through qPCR\u2010based genotyping. While no association was found between SNVs in IL1B and CASP1 with COVID\u201019 severity, the multivariate analysis revealed that the gain\u2010of\u2010function SNV in the NLRP3 gene (rs35829419) was associated with a protective effect against COVID\u201019\u2013related mortality. These findings suggest that genetic variations in the NLRP3 inflammasome may modulate the host response to SARS\u2010CoV\u20102, highlighting potential biomarkers for disease prognosis.<\/jats:p>","DOI":"10.1111\/iji.70021","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:27:00Z","timestamp":1761629220000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An NLRP3 Variant Protects Against Severe COVID\u201019: An Unexpected Contribution of Inflammasome Genetics in SARS\u2010CoV\u20102 Infection"],"prefix":"10.1111","volume":"53","author":[{"given":"Leandro Martin","family":"Paulino","sequence":"first","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Nunes Cordeiro","family":"Leal","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellyngton Matheus de Souza","family":"Santiago","sequence":"additional","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora de F\u00e1tima Almeida","family":"Donanzam","sequence":"additional","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lio Roberto Siqueira","family":"Ledesma","sequence":"additional","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda Silva","family":"Bertelli","sequence":"additional","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington Santos","family":"Fava","sequence":"additional","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carla Pereira","family":"Latini","sequence":"additional","affiliation":[{"name":"Lauro de Souza Lima Institute  Bauru SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pontillo","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, University of S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Venturini","sequence":"additional","affiliation":[{"name":"School of Medicine \u2010 Laboratory of infectious and parasitic diseases Federal University of Mato Grosso do Sul Campo Grande MS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asoc.2022.108973"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06355-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04826-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00478-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03053-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03570-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/421523"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4410-4415.2004"},{"key":"e_1_2_9_12_1","article-title":"Severe COVID\u201019 Patients Show a Dysregulation of the NLRP3 Inflammasome in Circulating Neutrophils","volume":"97","author":"Leal V. 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