{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T18:10:04Z","timestamp":1768241404932,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic hepatitis B (CHB) is a major risk factor for liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Genes involved in the JAK\/STAT signalling pathway play a critical role in the pathogenesis of HBV\u2010related liver diseases, especially HCC. Although\n                    <jats:italic>SOCS1<\/jats:italic>\n                    and\n                    <jats:italic>SOCS3<\/jats:italic>\n                    have been extensively studied, the role of SOCS6 in HBV infection and disease progression remains unclear. This study aimed to investigate the association between\n                    <jats:italic>SOCS6<\/jats:italic>\n                    gene polymorphisms and promoter methylation with HBV\u2010related liver diseases.\n                  <\/jats:p>\n                  <jats:p>\n                    This study examined\n                    <jats:italic>SOCS6<\/jats:italic>\n                    gene polymorphisms in a cohort of 335 patients with HBV\u2010related liver diseases (120 with CHB, 100 with LC and 115 with HCC) and 120 healthy controls (HCs). In addition,\n                    <jats:italic>SOCS6<\/jats:italic>\n                    promoter methylation was analysed in tumour and adjacent tissues from 41 HCC patients.\n                  <\/jats:p>\n                  <jats:p>\n                    We found that the\n                    <jats:italic>rs2062345GA<\/jats:italic>\n                    genotype and the dominant genetic model were associated with an increased risk of HBV infection and HCC. The\n                    <jats:italic>rs7228049GA<\/jats:italic>\n                    genotype increased the risk of LC and HCC. Conversely, the\n                    <jats:italic>rs7228049AA<\/jats:italic>\n                    genotype and the recessive model were associated with a reduced risk of CHB, LC and HCC. The SNPs rs2062345, rs7228049 and rs11151580 were related to several clinical parameters such as AST, albumin and prothrombin levels, platelet counts in LC and HCC patients. Promoter hypermethylation of\n                    <jats:italic>SOCS6<\/jats:italic>\n                    was more prevalent in tumour tissues, especially in larger tumours with poorer histological differentiation (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.01 and\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.05, respectively).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>SOCS6<\/jats:italic>\n                    gene variants and promoter methylation are associated with susceptibility and progression of HBV\u2010related liver diseases. These findings suggest their potential utility as useful prognostic biomarkers for HCC.\n                  <\/jats:p>","DOI":"10.1111\/iji.70023","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:33:36Z","timestamp":1761989616000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of SOCS6 Gene Polymorphisms and Promoter Hypermethylation With the Progression of Hepatitis B Virus Infection"],"prefix":"10.1111","volume":"53","author":[{"given":"Nguyen Viet","family":"Phuong","sequence":"first","affiliation":[{"name":"Institute of Biomedicine and Pharmacy Vietnam Military Medical University  Hanoi Vietnam"},{"name":"103 Military Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Van","family":"Dung","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy Vietnam Military Medical University  Hanoi Vietnam"},{"name":"103 Military Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Quang","family":"Nhut","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy Vietnam Military Medical University  Hanoi Vietnam"},{"name":"103 Military Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Van","family":"Khanh","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Thi Phuong","family":"Thao","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngo Thu","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Duc","family":"Ky","sequence":"additional","affiliation":[{"name":"Pathology and Molecular Biology Center Vietnam National Cancer Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Minh","family":"Hai","sequence":"additional","affiliation":[{"name":"103 Military Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Xuan","family":"Khai","sequence":"additional","affiliation":[{"name":"103 Military Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Viet","family":"Tien","sequence":"additional","affiliation":[{"name":"103 Military Hospital Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can Van","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Linh","family":"Toan","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Vietnam Military Medical University  Hanoi Vietnam"},{"name":"Vietnamese\u2010German Center for Medical Research (VG\u2010CARE) 108 Military Central Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7170-8810","authenticated-orcid":false,"given":"Hoang Van","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine and Pharmacy Vietnam Military Medical University  Hanoi Vietnam"},{"name":"Department of Pathophysiology Vietnam Military Medical University  Hanoi Vietnam"},{"name":"Vietnamese\u2010German Center for Medical Research (VG\u2010CARE) 108 Military Central Hospital  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0701-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313381200"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11101825"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2008.07.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.06.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.03.001"},{"issue":"5","key":"e_1_2_9_9_1","first-page":"S27","article-title":"WHO Classification of Digestive Tumors: The Fourth Edition","volume":"31","author":"Fl\u00e9jou J. 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