{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:12:54Z","timestamp":1790201574537,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Preeclampsia (PE) is a major pregnancy complication with considerable maternal and fetal morbidities. The recent evidence indicates that immunological factors have critical roles in PE pathogenesis. This study assessed the association between genetic variations in IL\u201035 components, specifically IL\u201012A (rs568408) and EBI3 (rs4740) polymorphisms, and PE susceptibility in an Iranian population. A case\u2010control study with 470 participants was carried out, and polymorphism detection was achieved by the PCR\u2010RFLP technique. Genetic analysis revealed distinct associations between IL\u201035 components polymorphisms and PE risk. For IL\u201012A rs568408, the AA mutant genotype significantly increased PE susceptibility (OR = 3.350,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007), with stronger associations in severe PE cases (OR = 5.048,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Similarly, the mutant allele showed risky effects in total group and severe subgroup (OR = 1.743,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001; OR = 2.307,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The EBI3 rs4740 polymorphism analysis showed that AA genotype carriers had a protective effect (OR = 0.495,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036), particularly noticeable in severe cases (OR = 0.409,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.037). In addition, the mutant allele demonstrated protective effects in the total PE, severe and particularly in early\u2010onset manifestations (OR = 0.651, OR = 0.559, OR = 0.478, respectively). Combined genotype analysis showed that IL\u201012A AA\/EBI3 GA carriers had the highest risk of severe, early\u2010onset PE (OR = 5.280,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.046, OR = 5.945,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038). This study provides a better understanding of the causes of PE and points out possible genetic markers to be used in its risk assessment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iji.70030","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:11:58Z","timestamp":1765174318000},"page":"144-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of IL\u201035 Subunits, IL\u201012A rs568408 and EBI3 rs4740, Gene Polymorphisms With Preeclampsia Risk"],"prefix":"10.1111","volume":"53","author":[{"given":"Mohammad","family":"Darvishzadeh","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Science University of Sistan and Baluchestan  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danial","family":"Jahantigh","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science University of Sistan and Baluchestan  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Forghani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Ghazaey Zidanloo","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology Kosar University of Bojnord  Bojnord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Preeclampsia: Clinical Features and Diagnosis","author":"August P.","year":"2017"},{"key":"e_1_2_9_3_1","first-page":"237","article-title":"Evaluation of IL\u201017 and IL\u201035 Serum Levels in Patients With Preeclampsia","volume":"20","author":"Batebi A.","year":"2019","journal-title":"Journal of Reproduction & Infertility"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13055"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1144170"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.648233"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\u2010conference.2019.199.1_MeetingAbstracts.A6088"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000670\u20100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000670\u20100"},{"key":"e_1_2_9_10_1","volume-title":"The Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response","author":"Dembic Z.","year":"2015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026\u2010021\u201009246\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.758554"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1267624"},{"key":"e_1_2_9_14_1","first-page":"296","article-title":"The Expression of T\u2010Helper Associated Transcription Factors and Cytokine Genes in Pre\u2010Eclampsia","volume":"13","author":"Gharesi\u2010Fard B.","year":"2016","journal-title":"Iranian Journal of 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