{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:57:14Z","timestamp":1773061034899,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The etiology of ankylosing spondylitis (AS) is complex and not yet fully understood. Interleukin\u20106 (IL\u20106), vitamin D and the vitamin D receptor (VDR) play an important role in modulating immune response, and Torque teno virus is considered a marker of immune status.<\/jats:p>\n                  <jats:p>\n                    This case\u2013control study aimed to investigate the predisposition to AS. A total of 85 patients with AS and 100 clinically healthy individuals were included.\n                    <jats:italic>VDR<\/jats:italic>\n                    polymorphisms (rs2228570, rs1544410, rs7975232, rs731236) were genotyped using the PCR\u2010RFLP technique, while for the\n                    <jats:italic>IL<\/jats:italic>\n                    \u20106 \u2010174 G&gt;C (rs1800795) polymorphism the tetra\u2010primer ARMS\u2010PCR technique was used. The presence of TTV was detected using the hemi\u2010nested PCR technique.\n                  <\/jats:p>\n                  <jats:p>\n                    Our findings indicate a statistically significant association between TTV and AS (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.035). C allele of both rs1800795 polymorphism in main groups (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.027) and rs731236 polymorphism in women subgroups (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.036) may be linked to an increased susceptibility to AS. However, none of these associations reach statistical significance after Bonferroni correction. Furthermore, within female subgroups, a significant association was found between the T allele of rs1544410 polymorphism and AS (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.000038, corrected\n                    <jats:italic>p<\/jats:italic>\n                    = 0.00076). A significant association was also observed between the TT genotype of rs2228570 polymorphism, TTV and AS (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029). Haplotype analysis revealed that certain VDR haplotypes may confer either a protective effect against AS or an increased risk of developing the condition. Notably, rs1544410 polymorphism or a linked polymorphism may influence AS susceptibility. In conclusion, our data suggest that TTV and\n                    <jats:italic>VDR<\/jats:italic>\n                    polymorphisms may be associated with an increased risk of developing AS, indicating that these markers could potentially be used in the future for earlier diagnosis and more targeted treatment of the disease.\n                  <\/jats:p>","DOI":"10.1111\/iji.70033","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:26:39Z","timestamp":1768292799000},"page":"157-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating Associations Between Ankylosing Spondylitis, Torque Teno Virus and Polymorphisms in Interleukin 6 and Vitamin D Receptor Genes"],"prefix":"10.1111","volume":"53","author":[{"given":"D\u0103nu\u021b","family":"Cimponeriu","sequence":"first","affiliation":[{"name":"Department of Genetics Faculty of Biology University of Bucharest  Bucharest 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Emergency University Hospital Dr. Carol Davila  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Nica","sequence":"additional","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"M\u0103ciuc\u0103","sequence":"additional","affiliation":[{"name":"Department of Genetics Faculty of Biology University of Bucharest  Bucharest 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