{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:57:25Z","timestamp":1773061045243,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Peri\u2010implantitis is a pathological condition occurring in tissues around dental implants. This study aims to analyse the effect of TGF\u2010\u03b21 rs1800470 polymorphism on peri\u2010implantitis. A total of 160 patients with implants without peri\u2010implantitis and 160 patients with peri\u2010implantitis were recruited from the clinic for this study. The genotype of TGF\u2010\u03b21 rs1800470 and TGF\u2010\u03b21 expression were detected by TaqMan\u2010qPCR and RT\u2010qPCR, respectively. Distributions of genotypes and allele frequencies were analysed by the chi\u2010square test. A Hardy\u2013Weinberg equilibrium (HWE) test was performed to detect whether the gene distribution was established. The diagnostic value of TGF\u2010\u03b21 for peri\u2010implantitis was analysed by the ROC curve. TGF\u2010\u03b21 expression was significantly lower in peri\u2010implantitis patients, which has diagnostic significance for peri\u2010implantitis. TGF\u2010\u03b21 rs1800470 genotypic distribution conformed to the Hardy\u2013Weinberg equilibrium test. CT and TT genotypes were significantly correlated with the development of peri\u2010implantitis (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004, OR\u00a0=\u00a02.107, 95% CI\u00a0=\u00a01.259\u20133.527). CT and TT genotypes were validated as causative genotypes for peri\u2010implantitis. Polymorphisms at the TGF\u2010\u03b21 rs1800470 locus have an impact on the development of peri\u2010implantitis, and CT and TT genotypes increase the risk of developing peri\u2010implantitis.\n                  <\/jats:p>","DOI":"10.1111\/iji.70034","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T11:40:19Z","timestamp":1767958819000},"page":"171-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The rs1800470 Polymorphism of TGF\u2010\u03b21 Influences the Incidence of Peri\u2010Implantitis"],"prefix":"10.1111","volume":"53","author":[{"given":"Shiqi","family":"Liu","sequence":"first","affiliation":[{"name":"Oral Medicine Center Aviation General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of\u00a0General Dentistry Wuxi Stomatology Hospital  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of\u00a0General Dentistry Wuxi Stomatology Hospital  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of\u00a0Endodontics Wuxi Stomatology Hospital  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of\u00a0General Dentistry Wuxi Stomatology Hospital  Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Zibo Maternal and Child Care Hospital  Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13401"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1058532"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13729"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101921-045939"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231161005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj11050134"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01764-w"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200910"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.891122"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"S103","article-title":"Classification and Diagnosis of Aggressive Periodontitis","volume":"89","author":"Fine D. 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