{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:01:34Z","timestamp":1777950094399,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Celiac disease (CD) risk conferred by HLA\u2010DQ2 and DQ8 varies significantly across populations. In north India, where CD is as prevalent as in European populations, reports on the association of HLA\u2010DQ2 and DQ8 with CD are limited. In a north Indian CD case\u2010control cohort (459 CD and 450 controls), known CD\u2010associated risk HLA\u2010DQ alleles, HLA\u2010DQA1*05:01\/02:01\/03:01 and HLA\u2010DQB1*02\/*03:02, were genotyped using SSP\u2010PCR to uncover their frequency and association with CD. Published dense Illumina_Immunochip genotyping data of the study cohort were used to identify proxy\u2010SNPs for HLA\u2010DQ genotypes and their alleles. We also investigated the correlation between common CD phenotypes and DQ2\/8 genotypes. Ninety\u2010nine percent\u00a0of the CD patients were found to carry HLA\u2010DQ2.5, DQ2.2 or 8. HLA\u2010DQA1*05:01 (OR = 5.86 [4.39\u20137.81],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001) and HLA\u2010DQB1*02 (OR = 16.61 [11.37\u201324.25],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001) were identified as the strongest susceptibility alleles. HLA\u2010DQ2.5 was present in 92% of patients and conferred the highest CD risk (OR = 29.01 [19.56\u201343.00],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.00001), while DQ8 appeared protective (OR = 0.42 [0.25\u20130.70],\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). HLA\u2010DQ2.5\/8 and HLA\u2010DQ2.5\/2.2 were found significantly associated with serum anti\u2010tTG\u2010IgA and skin conditions, respectively, among CD patients. rs1129740, rs9273012 and rs7744001 were identified as proxy\u2010SNPs to efficiently predict the presence\/absence of DQ2.5, DQ2.2, DQ8 and its alleles. This was the first well\u2010powered study to evaluate the susceptibility of HLA\u2010DQ in CD among the north Indian population. HLA\u2010DQ2.5 showed a strong association with CD, conferring a higher disease risk, while DQ8 appeared protective, and the contribution of DQ2.2 was inconclusive. Three proxy\u2010SNPs, rs1129740, rs9273012 and rs7744001, could be utilized to predict HLA\u2010DQ genotypes as a cost\u2010effective alternative for CD risk assessment.\n                  <\/jats:p>","DOI":"10.1111\/iji.70045","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:06:40Z","timestamp":1773036400000},"page":"259-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["To Study the Association of HLA\u2010DQ2\/8 With Celiac Disease and Identifying Proxy\u2010SNPs for Predicting Their Presence in North Indian Population"],"prefix":"10.1111","volume":"53","author":[{"given":"Priyanka","family":"Tiwari","sequence":"first","affiliation":[{"name":"Immunogenomics Laboratory, Department of Human Genetics and Molecular Medicine, School of Health Sciences Central University of Punjab  Bathinda India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BK","family":"Thelma","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Delhi South Campus  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[{"name":"Department of Medicine Dayanand Medical College and Hospital  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabyasachi","family":"Senapati","sequence":"additional","affiliation":[{"name":"Immunogenomics Laboratory, Department of Human Genetics and Molecular Medicine, School of Health Sciences Central University of Punjab  Bathinda India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-040210-092915"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"4926","article-title":"HLA\u2010DQ Genotyping of Celiac Disease Among Syrian Patients","volume":"25","author":"Alhabbal A.","year":"2021","journal-title":"Annals of the Romanian Society for Cell Biology"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"174","article-title":"HLA\u2010DQ Genotyping in Celiac Disease in Western India","volume":"36","author":"Amarapurkar D. 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