{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:48:24Z","timestamp":1791888504977,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Peri\u2010implantitis (PI) is a common inflammatory disease that threatens the stability of dental implants. This study investigated whether the promoter polymorphism rs731384 of the miR\u2010130a gene is linked to PI susceptibility and further explored the functional role of miR\u2010130a\u20105p in inflammatory responses and osteoblast viability. A total of 143 patients without PI and 127 patients with PI were gathered in this study. MassARRAY was used to genotype rs731384. Saliva samples were collected to measure miR\u2010130a\u20105p expression (via reverse transcriptase\u2010polymerase chain reaction [RT\u2010PCR]) and inflammatory cytokine levels (including interleukin [IL]\u20101\u03b2, IL\u20106 and tumour necrosis factor [TNF]\u2010\u03b1, via enzyme\u2010linked immunosorbent assay [ELISA]). In vitro inflammation model was established by treating hFOB1.19 human osteoblasts with lipopolysaccharide (LPS). The functional role of miR\u2010130a\u20105p was assessed by transfecting cells with a miR\u2010130a\u20105p inhibitor and evaluating its effects on cell viability, apoptosis and cytokine release in the supernatants. Bioinformatic databases (miRDB, ENCORI and TargetScan) were utilized to predict downstream target genes and pathways. A Positive association has been discovered between rs731384 and PI susceptibility under GA versus GG (odds ratio [OR]\u00a0=\u00a01.758, 95% confidence interval [CI]\u00a0=\u00a01.017\u20133.036), A versus G (OR\u00a0=\u00a01.779, 95% CI\u00a0=\u00a01.140\u20132.778), and GA\u00a0+\u00a0AA versus GG (OR\u00a0=\u00a01.867, 95% CI\u00a0=\u00a01.110\u20133.140) models. Upregulated miR\u2010130a\u20105p showed promising diagnostic value for distinguishing PI from healthy controls (area under the curve [AUC]\u00a0=\u00a00.858, sensitivity\u00a0=\u00a080.31%, specificity\u00a0=\u00a079.02%). Spearman analysis revealed a positive correlation between miR\u2010130a\u20105p and periodontal parameters as well as inflammation factors (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1 and C\u2010reactive protein [CRP]). The miR\u2010130a inhibitor reversed the LPS\u2010induced reduction in cell viability, the increase of apoptosis and the enhancement of IL\u20101\u03b2, IL\u20106 and TNF\u2010\u03b1 concentrations. Bioinformatics predicted that miR\u2010130a\u20105p targets genes enriched in TGF\u2010\u03b2, Hippo and FoxO signalling pathways. The mir\u2010130a\u20105p rs731384 polymorphism is positively correlated with PI susceptibility. High miR\u2010130a\u20105p may contribute to the diagnosis of PI from healthy controls. The inflammation and metabolism of bone tissue in PI may be significantly influenced by miR\u2010130a.<\/jats:p>","DOI":"10.1111\/iji.70062","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:10:46Z","timestamp":1791886246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of miR\u2010130a\u20105p rs731384 With the Susceptibility of Peri\u2010Implantitis and the Function of miR\u2010130a\u20105p in Peri\u2010Implantitis"],"prefix":"10.1111","author":[{"given":"Yong","family":"Li","sequence":"first","affiliation":[{"name":"Center of Stomatology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery General Hospital of Ningxia Medical University  Yinchuan Ningxia People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Stomatology Geriatric Hospital Affiliated to Wuhan University of Science and Technology  Wuhan Hubei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Affiliated Rehabilitation Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010023\u201000774\u2010x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2023.04.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14242784"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.94863"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1533468"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010014\u20100252\u20100"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1517154"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42074"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010023\u201000835\u20107"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13143225"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.34172\/joddd.40958"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1466417"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.77649"},{"key":"e_1_2_12_16_1","first-page":"323","article-title":"Natural Resistance Associated Macrophage Protein 1 Gene Polymorphism Is Associated With Chronic Periodontitis Not Peri\u2010Implantitis in an Iranian Population: A Cross Sectional Study","volume":"54","author":"Kadkhodazadeh M.","year":"2016","journal-title":"Acta Medica Iranica"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094653"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911877"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316794"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13982"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.391306"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15092115"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2022.08.001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccs3.70013"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12688"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010024\u201001334\u2010y"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105366"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511425045"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2021.11.014"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294236"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201085528\u20108"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21\u20100419"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114727"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2022.3342"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010023\u201000918\u20109"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2024.1462845"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431x2023e12989"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iji.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:10:47Z","timestamp":1791886247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":36,"alternative-id":["10.1111\/iji.70062"],"URL":"https:\/\/doi.org\/10.1111\/iji.70062","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}