{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:14Z","timestamp":1790154674995,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","award":["00210761"],"award-info":[{"award-number":["00210761"]}],"id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","award":["00230841"],"award-info":[{"award-number":["00230841"]}],"id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005609","name":"Turun Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022768","name":"Maire Lisko Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","award":["26006205"],"award-info":[{"award-number":["26006205"]}],"id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Genetic factors that modulate immune regulation are increasingly recognised as contributors to the heterogeneity and clinical course of autoimmune diseases. Polymorphisms of protein tyrosine phosphatase non\u2010receptor type 22 (PTPN22) are associated with several autoimmune diseases. We aimed to investigate the association of\n                    <jats:italic>PTPN22<\/jats:italic>\n                    rs2476601 polymorphism (C1858T, R620W) with juvenile idiopathic arthritis (JIA) subtypes, disease activity and treatment response. A total of 105 patients with diagnosed JIA were recruited. Blood samples were collected, and\n                    <jats:italic>PTPN22<\/jats:italic>\n                    polymorphism was analysed and compared to data from the 1000 Genomes. The\n                    <jats:italic>PTPN22<\/jats:italic>\n                    rs2476601 A\u2010allele was associated with increased JIA risk (OR: 1.71; 95% CI, 1.02\u20132.96;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.043), while overall genotype frequency in patients did not significantly differ from controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.086). Variant genotypes (AG\/AA) were enriched in polyarticular JIA (p\u2010JIA; OR: 2.27; 95% CI, 1.04\u20134.96;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.037). All patients who developed uveitis had either ANA positivity or a\n                    <jats:italic>PTPN22<\/jats:italic>\n                    variant genotype. None of ANA\u2010negative patients with the\n                    <jats:italic>PTPN22<\/jats:italic>\n                    wild\u2010type genotype (GG) were diagnosed with uveitis (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.044). Across three time points, disease activity improved significantly in both o\u2010JIA and p\u2010JIA. In o\u2010JIA, ESR levels were persistently higher in the\n                    <jats:italic>PTPN22<\/jats:italic>\n                    GG carriers. In contrast, in p\u2010JIA,\n                    <jats:italic>PTPN22<\/jats:italic>\n                    AG\/AA genotype consistently showed higher active joint counts over time than those with GG genotype. Our present data deepen the understanding of the role of\n                    <jats:italic>PTPN22<\/jats:italic>\n                    as a susceptibility factor in JIA, particularly in p\u2010JIA. The observed associations suggest that PTPN22 polymorphism may contribute to disease heterogeneity and disease course in selected JIA subgroups.\n                  <\/jats:p>","DOI":"10.1111\/iji.70069","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:48:56Z","timestamp":1790153336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of PTPN22 Polymorphism on Juvenile Idiopathic Arthritis Subtypes and Disease Activity in a Finnish Study Population"],"prefix":"10.1111","author":[{"given":"Sonja","family":"Kvist","sequence":"first","affiliation":[{"name":"Institute of Biomedicine, Research Centre for Infections and Immunity University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Ter\u00e4sj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Research Centre for Infections and Immunity University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Rahikkala","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital  Turku Finland"},{"name":"Research Unit of Clinical Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Mertsola","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Research Centre for Infections and Immunity University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milja","family":"M\u00f6tt\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushui","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Research Centre for Infections and Immunity University of Turku  Turku Finland"},{"name":"InFLAMES Research Flagship Centre University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010019\u201004246\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12919"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.032"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.04.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.067454"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/429096"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.10.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.70005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2017.04.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2614"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546\u20100096\u201011\u201040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161\u20106420(01)00773\u20104"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1626082"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005473\u20108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/TAN.12143"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.909020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.05.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010023\u201002888\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397116666201216164013"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40216"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158323"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000637"},{"issue":"2","key":"e_1_2_10_25_1","first-page":"390","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty R. 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