{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:51:52Z","timestamp":1761663112386},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1086,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Portal vein thrombosis (<jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>) is caused by local and systemic prothrombotic risk factors. In this case\u2010control study, we evaluated the use of the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>actor <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>a\u2010antithrombin complex (<jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>) complex assay as a hypercoagulability marker in patients with <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two different groups of cases were considered: (i) n\u00a0=\u00a012 noncirrhotic <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content> patients, (ii) n\u00a0=\u00a033 cirrhotic patients with <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>. Controls were sex and age\u2010matched healthy volunteers and cirrhotic subjects without <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of the <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> complex were significantly higher in noncirrhotic <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content> subjects (132\u00a0\u00b1\u00a032\u00a0p<jats:sc>m<\/jats:sc>) than in healthy volunteers (108\u00a0\u00b1\u00a018\u00a0p<jats:sc>m<\/jats:sc>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.04). No significant difference in <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> complexes was seen between cirrhotic patients with (64\u00a0\u00b1\u00a020\u00a0p<jats:sc>m<\/jats:sc>) or without (61\u00a0\u00b1\u00a024\u00a0p<jats:sc>m<\/jats:sc>) <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>. A linear correlation was seen between <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a in noncirrhotic <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content> subjects. In cirrhotic patients, <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> complexes depended on both <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a and <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results confirm the utility of the <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> assay in identifying the hypercoagulable state of noncirrhotic patients because of a previous thrombotic event.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12003","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T08:57:13Z","timestamp":1347267433000},"page":"101-105","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Factor <scp>VII<\/scp>a\u2010antithrombin complexes in patients with non\u2010neoplastic portal vein thrombosis with and without cirrhosis"],"prefix":"10.1111","volume":"35","author":[{"given":"V.","family":"Rossetto","sequence":"first","affiliation":[{"name":"Department of Cardiologic, Thoracic, and Vascular Sciences 2nd Chair of Internal Medicine University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Spiezia","sequence":"additional","affiliation":[{"name":"Department of Cardiologic, Thoracic, and Vascular Sciences 2nd Chair of Internal Medicine University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Senzolo","sequence":"additional","affiliation":[{"name":"Department of Surgical and Gastroenterological Sciences Gastroenterology Unit University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Surgical and Gastroenterological Sciences Gastroenterology Unit University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gavasso","sequence":"additional","affiliation":[{"name":"Department of Cardiologic, Thoracic, and Vascular Sciences 2nd Chair of Internal Medicine University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Woodhams","sequence":"additional","affiliation":[{"name":"R &amp; D, Diagnostica Stago Gennevilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Simioni","sequence":"additional","affiliation":[{"name":"Department of Cardiologic, Thoracic, and Vascular Sciences 2nd Chair of Internal Medicine University of Padua Medical School Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.11.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.09.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03937.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-08-0606"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10516"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01888505"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.05.020"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:52:00Z","timestamp":1698648720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,10]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/ijlh.12003"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12003","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,10]]}}}