{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:38:41Z","timestamp":1768513121148,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1009,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Iron\u2010deficient erythropoiesis attributable to nutritional deficiency is the most common cause of anemia in early childhood. Beckman Coulter has proposed new parameters: red blood cell size factor (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f) and low hemoglobin density (<jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>%).<jats:disp-formula><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" position=\"anchor\" xlink:href=\"graphic\/ijlh12030-math-0001.gif\"><jats:alt-text>urn:x-wiley:17515521:media:ijlh12030:ijlh12030-math-0001<\/jats:alt-text><\/jats:graphic><\/jats:disp-formula><\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>The aims of the present communication were to establish reference ranges (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f and <jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>% in a healthy pediatric population; to evaluate clinical utility of these parameters in the diagnosis of iron\u2010deficiency anemia (<jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>); and to compare <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f and <jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>% with <jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content>\u2010He.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred healthy infants and 51 with <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> were analyzed on Coulter <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>750 and Sysmex <jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content>2000i analyzers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f in children aged 0.5\u20136\u00a0years, 82.2\u2013102.0 and 83.7\u2013103.1\u00a0fl in the group aged 6\u201018\u00a0years. <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>% was 1.1\u20139.0%. <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis for <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f and <jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>% in the diagnosis of <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content> showed an <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> 0.8460 and 0.8654, respectively. The best <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f value to detect a restricted erythropoiesis was 89fl, sensitivity 92%, specificity 81%. <jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>% optimal cutoff point was 6.0%, sensitivity 80%, and specificity 88%. Good correlation was observed between these parameters with Ret\u2010He, r\u00a0=\u00a00.888 and r\u00a0=\u00a0\u22120.790, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>f and <jats:styled-content style=\"fixed-case\">LHD<\/jats:styled-content>% could be useful tools in the screening of <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>. These parameters can be obtained in the course of routine blood counts, with no additional cost or need for more blood sampling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12030","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T09:53:54Z","timestamp":1353923634000},"page":"400-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Utility of new mature erythrocyte and reticulocyte indices in screening for iron\u2010deficiency anemia in a pediatric population"],"prefix":"10.1111","volume":"35","author":[{"given":"V.","family":"Osta","sequence":"first","affiliation":[{"name":"Central Laboratory Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Caldirola","sequence":"additional","affiliation":[{"name":"Central Laboratory Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Hematology Service Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. I.","family":"Marcone","sequence":"additional","affiliation":[{"name":"Central Laboratory Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tissera","sequence":"additional","affiliation":[{"name":"Central Laboratory Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pennesi","sequence":"additional","affiliation":[{"name":"Hematology Service Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ayuso","sequence":"additional","affiliation":[{"name":"Central Laboratory Ricardo Guti\u00e9rrez Children's Hospital Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80177-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109053251004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.4.e51"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1182\/blood.V84.6.1697.1697","article-title":"Regulation of iron balance in humans","volume":"84","author":"Finc C","year":"1994","journal-title":"Blood"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01237.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005990050011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2009.04.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-84842003000200005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00812.x"},{"key":"e_1_2_6_11_1","first-page":"1422","article-title":"Reticulocyte indices rapidly reflect an increase in iron availability for erythropoiesis","volume":"88","author":"Kotissari S","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/49.10.1573"},{"issue":"3","key":"e_1_2_6_13_1","first-page":"11","article-title":"NKF\u2010K\/DOQI Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease in adults","volume":"47","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/EK3C7CTDKNVPXVTN"},{"key":"e_1_2_6_15_1","first-page":"1133","article-title":"Clinical utility of the new Sysmex XE 2100 parameter \u2013 reticulocyte haemoglobin equivalent \u2013 in the diagnosis of anemia","volume":"90","author":"Canals C","year":"2005","journal-title":"Hematologica"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/W65295DTUWK7U1HH"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.030254"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21090"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2008.01088.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2008.01127.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01238.x"},{"key":"e_1_2_6_22_1","unstructured":"ZiniG MachinS BriggsC et\u00a0al.Multicentric evaluation of Coulter MCH and the new derived SigMCHC\u00aeparameters versus CHr and%Hypo for the assessment of iron metabolism disturbances.2006. ISLH XIXth International Symposium Amsterdam."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.207"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.06037"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.23.2225"},{"key":"e_1_2_6_26_1","first-page":"549","article-title":"Mature erythrocyte indices: new markers of iron availability","volume":"90","author":"Bovy C","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_27_1","first-page":"13","article-title":"Usefulness of reticulocyte indices in the early detection of functional iron deficiency and in the response to therapy with vitamin B12","volume":"13","author":"Temporin V","year":"1998","journal-title":"Automated Blood Cytol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2003.00486.x"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12030","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:54:50Z","timestamp":1696370090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,26]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/ijlh.12030"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12030","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,26]]},"assertion":[{"value":"2012-11-26","name":"published_online","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]}}