{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:24:45Z","timestamp":1696397085994},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":991,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>After a first survey in 2001, the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>utch <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssociation of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ematological <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>aboratory <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch (<jats:styled-content style=\"fixed-case\">VHL<\/jats:styled-content>) advised its members to adopt a basic protocol for haemoglobinopathy carrier detection and to provide genetic information with all positive results to allow health\u2010care professionals to inform carriers about potential genetic risks. This article reports on the compliance with these recommendations and their consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical chemists of all 106 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>utch laboratories were invited to answer a survey on patient population, diagnostic techniques used, (self\u2010reported) knowledge, use and effect of the additional information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average increase in diagnostic output was over 60% and the recommended basic protocol was applied by 65% of the laboratories. Over 84% of the laboratories reported to be aware of the additional recommendations and 77% to be using them. Most laboratories with limited diagnostic requests were still sending their cases to other laboratories and included the genetic information received from these laboratories in their diagnostic reports. The effect of information on subsequent \u2018family analysis\u2019 was estimated to be between 26 and 50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study shows an increase in diagnostic potential for haemoglobinopathy over the last decade, especially in the larger cities. Low \u2018family testing\u2019 rates were mostly found in areas with lower carrier prevalence or associated with local reluctance to pass the information to carriers. In spite of a dramatic improvement, too many carriers are still not informed because of lack of awareness among health\u2010care providers and more education is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12038","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T12:47:03Z","timestamp":1355489223000},"page":"428-435","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Basic haemoglobinopathy diagnostics in <scp>D<\/scp>utch laboratories; providing an informative test result"],"prefix":"10.1111","volume":"35","author":[{"given":"J. O.","family":"Kaufmann","sequence":"first","affiliation":[{"name":"Hemoglobinopathies Laboratory LDGA, Clinical Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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