{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:30:35Z","timestamp":1773685835293,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T00:00:00Z","timestamp":1356566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":978,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>As most hematology cell analyzers, the different parameters of Sysmex <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>\u20105000\u2122 are little informative in the qualitative analysis of lymphoid cells, and especially when the lymphocyte count is below 4\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (i.e., \u2018normal\u2019). The aim of our study was to investigate whether some parameters and\/or \u2018flags\u2019 not routinely provided by this analyzer, but reachable by operator could be reliable to define rules of slide review in absence of common qualitative and quantitative alarms particularly in case of \u2018normal\u2019 lymphocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples from 13 mantle cell lymphoma fully annotated cases, and 180 control specimens were studied with <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ysmex <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>\u20105000\u2122 analyzer. All cases did not present any anomalies in common quantitative and structural parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using the method of area under the curve and <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve analysis, we described a novel threshold of alarm <jats:styled-content style=\"fixed-case\">VAL<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">ABN LYMPH<\/jats:styled-content> (\u226540 instead of 100 defined by <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ysmex), as well as a pertinent <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> threshold (\u226589). The combination of these thresholds allowed defining a rule of slide review in context of \u2018normal\u2019 lymphocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among the parameters provided by the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ysmex <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>\u20105000\u2122 analyzer, the combination of the alarm <jats:styled-content style=\"fixed-case\">VAL<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">ABN LYMPH<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> value, routinely available on a simple blood analysis appears particularly informative to trigger slide review in a context of \u2018normal\u2019 lymphocyte count with a good sensitivity (85%) to detect circulating lymphoma cells and with &lt;1% of false positive results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12042","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T12:52:06Z","timestamp":1356612726000},"page":"510-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pertinence of the <scp>S<\/scp>ysmex <scp>XE<\/scp>\u20105000\u2122 parameters: rule of slide review in a context of \u2018normal\u2019 lymphocyte count (defined from control and mantle cell lymphoma blood specimens)"],"prefix":"10.1111","volume":"35","author":[{"given":"J.","family":"Chhuy","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Morel","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre B\u00e9nite France"},{"name":"UMR5239 Pathologies des cellules lympho\u00efdes Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Goeddert","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010P.","family":"Magaud","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre B\u00e9nite France"},{"name":"UMR5239 Pathologies des cellules lympho\u00efdes Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Felman","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre B\u00e9nite France"},{"name":"UMR5239 Pathologies des cellules lympho\u00efdes Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Baseggio","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Pierre B\u00e9nite France"},{"name":"UMR5239 Pathologies des cellules lympho\u00efdes Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-596-LPATRO"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.05019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22715"},{"key":"e_1_2_6_5_1","volume-title":"World Health Organization classification of Tumours of Haematopoietic and Lymphoid 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Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:54:08Z","timestamp":1696362848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,27]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/ijlh.12042"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12042","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,27]]},"assertion":[{"value":"2012-12-27","name":"published_online","label":"Published 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