{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:22:09Z","timestamp":1790382129636,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,9]],"date-time":"2013-03-09T00:00:00Z","timestamp":1362787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":906,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Summary<\/jats:title>The foundation of laboratory hematologic diagnosis is the complete blood count and review of the peripheral smear. In patients with anemia, the peripheral smear permits interpretation of diagnostically significant red blood cell (RBC<\/jats:styled-content>) findings. These include assessment of RBC<\/jats:styled-content> shape, size, color, inclusions, and arrangement. Abnormalities of RBC<\/jats:styled-content> shape and other RBC<\/jats:styled-content> features can provide key information in establishing a differential diagnosis. In patients with microcytic anemia, RBC<\/jats:styled-content> morphology can increase or decrease the diagnostic likelihood of thalassemia. In normocytic anemias, morphology can assist in differentiating among blood loss, marrow failure, and hemolysis\u2014and in hemolysis, RBC<\/jats:styled-content> findings can suggest specific etiologies. In macrocytic anemias, RBC<\/jats:styled-content> morphology can help guide the diagnostic considerations to either megaloblastic or nonmegaloblastic causes. Like all laboratory tests, RBC<\/jats:styled-content> morphologies must be interpreted with caution, particularly in infants and children. When used properly, RBC<\/jats:styled-content> morphology can be a key tool for laboratory hematology professionals to recommend appropriate clinical and laboratory follow\u2010up and to select the best tests for definitive diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12082","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T22:03:39Z","timestamp":1363125819000},"page":"351-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":194,"title":["Red blood cell morphology"],"prefix":"10.1111","volume":"35","author":[{"given":"J.","family":"Ford","sequence":"first","affiliation":[{"name":"Division of Hematopathology BC Children's Hospital Faculty of Medicine University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/14.8.509"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00871.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118158562.ch3"},{"key":"e_1_2_3_5_1","first-page":"1465","article-title":"Seizures in a 10\u2010week\u2010old infant: lead poisoning from an unexpected source","volume":"145","author":"Lockitch G","year":"1991","journal-title":"Can Med Assoc J"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200X.2002.01636.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00853.x"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408360390247832"},{"key":"e_1_2_3_9_1","first-page":"1012","article-title":"Screening for alpha\u2010thalassemia. 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