{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:16:43Z","timestamp":1773958603227,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":783,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Several factors influence the severity of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>lasmodium falciparum<\/jats:italic>; here, we investigate the impact of alpha+\u2010thalassaemia genotype on <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> parasitemia and prevalence of severe anaemia amongst microcytic children from <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>umasi, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>hana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred and thirty\u2010two children (\u226410\u00a0years) with <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> were categorised into normocytic and microcytic (mean cell volume \u226476\u00a0fL). Microcytic individuals were genotyped for the \u2212\u03b1<jats:sup>3.7<\/jats:sup>deletional thalassaemia mutation and parasite densities determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst microcytic patients both parasite densities and prevalence of severe malaria parasitemia (\u2265100\u00a0000\/\u03bcL) were significantly lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in the presence of an alpha+\u2010thalassaemia genotype compared with non\u2010alpha+\u2010thalassaemia genotype. There was no evidence that alpha+\u2010thalassaemia protected against severe anaemia. The protection conferred by alpha\u2010thalassaemia genotype against severe <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> parasitemia did not change with increasing age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The severity of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0falciparum<\/jats:italic> parasitemia was significantly lower in both the homozygous and heterozygous alpha+\u2010thalassaemia groups compared with microcytic individuals with non\u2010alpha+\u2010thalassaemia genotype. The protective effect, from severe malaria, of the alpha+\u2010thalassaemia allele does not alter with age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12122","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T07:32:56Z","timestamp":1373441576000},"page":"62-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An investigation of the protective effect of alpha+\u2010thalassaemia against severe <i><scp>P<\/scp>lasmodium falciparum<\/i> amongst children in <scp>K<\/scp>umasi, <scp>G<\/scp>hana"],"prefix":"10.1111","volume":"36","author":[{"given":"C.","family":"Opoku\u2010Okrah","sequence":"first","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology Kumasi Ghana"},{"name":"University of Westminster School of Life Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gordge","sequence":"additional","affiliation":[{"name":"University of Westminster School of Life Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kweku Nakua","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Abgenyega","sequence":"additional","affiliation":[{"name":"Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Parry","sequence":"additional","affiliation":[{"name":"University of Westminster School of Life Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Robertson","sequence":"additional","affiliation":[{"name":"University of Westminster School of Life Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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