{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:00:15Z","timestamp":1790398815867,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":698,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The oxidative process plays a fundamental role in the pathophysiology of sickle cell anemia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>), and population and environmental characteristics may influence redox balance. The aim of this study was to evaluate lipid peroxidation and antioxidant capacity in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>razilian <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> carriers undergoing different therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples from 270 individuals were analyzed (Hb <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a068; Hb <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a053, and Hb <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a0149). Hemoglobin genotypes were assessed through cytological, electrophoretic, chromatographic, and molecular methods. Plasma lipid peroxidation and antioxidant capacity were measured by spectrophotometric methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> who used iron\u2010chelating drugs combined with hydroxyurea, associated with regular transfusions, showed lower levels of <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.05), higher levels of <jats:styled-content style=\"fixed-case\">TEAC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.01), and lower <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEAC<\/jats:styled-content> ratio (R\u00a0=\u00a0255.8). The redox profile of Hb <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> subjects was not statistically different (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05) from that of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest that oxidative stress is lower in the patients with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> who received regular blood transfusions associated with the combined use of <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> and iron chelators than the group received only <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content>. The redox system of the Hb <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> carriers is compatible with the control group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12154","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:23:48Z","timestamp":1381544628000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of \u03b2<sup>S<\/sup> allele in the lipid peroxidation and antioxidant capacity parameters"],"prefix":"10.1111","volume":"36","author":[{"given":"E. L. T.","family":"Shimauti","sequence":"first","affiliation":[{"name":"Department of Biology Laboratory of Hemoglobin and Genetics of Hematological Diseases Universidade Estadual Paulista (UNESP) S\u00e3o Jos\u00e9 do Rio Preto Brazil"},{"name":"Department of Clinical Analysis and Biomedicine Universidade Estadual de Maring\u00e1 (UEM) Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Belini Junior","sequence":"additional","affiliation":[{"name":"Department of Biology Laboratory of Hemoglobin and Genetics of Hematological Diseases Universidade Estadual Paulista (UNESP) S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M. da S. V.","family":"Baracioli","sequence":"additional","affiliation":[{"name":"Department of Biology Laboratory of Hemoglobin and Genetics of Hematological Diseases Universidade Estadual Paulista (UNESP) S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Statistics Department UEM Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Granzotto","sequence":"additional","affiliation":[{"name":"Statistics Department UEM Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Chemistry Department UNESP S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G. H.","family":"Silva","sequence":"additional","affiliation":[{"name":"Chemistry Department UNESP S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ricci Junior","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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