{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:40:14Z","timestamp":1780512014337,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":677,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anemia and macrocytosis are well\u2010defined expected hematologic findings of vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 and folate deficiency; however, some previous studies did not show a significant association of subnormal <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 with anemia and macrocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 17\u00a0713 laboratory patient records to evaluate vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 and folate levels in relation to anemia and macrocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In an age\u2010 and sex\u2010adjusted logistic regression model, low <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 status but not marginal <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 status was significantly associated with anemia [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s respectively, 1.291 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.182\u20131.410), 1.022 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.943\u20131.108)] and macrocytosis [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s, respectively, 3.853 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 3.121\u20134.756), 1.031 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.770\u20131.381)]. Also low folate status but not marginal folate status was significantly associated with anemia [adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s, respectively, 1.819 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.372\u20132.411), 1.101 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.931\u20131.301)] and macrocytosis [adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s, respectively, 2.945 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.747\u20134.965), 1.228 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.795\u20131.898)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that increased anemia and macrocytosis are observed at values below commonly used <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 lower\u2010reference thresholds. Determining a hematologic cutoff value may help physicians in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12158","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T13:24:10Z","timestamp":1382621050000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vitamin B12 and folate deficiency: should we use a different cutoff value for hematologic disorders?"],"prefix":"10.1111","volume":"36","author":[{"given":"B.","family":"Toprak","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Tepecik Training and Research Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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