{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:28:14Z","timestamp":1768339694521,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T00:00:00Z","timestamp":1389312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":599,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea","award":["2013-1320070"],"award-info":[{"award-number":["2013-1320070"]}]},{"name":"National Research Foundation of Korea (NRF) and grants funded by the Korea government (MEST)","award":["2011-0015304"],"award-info":[{"award-number":["2011-0015304"]}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Unreported parameters produced by automated blood cell counter, particularly large unstained cells (<jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content>) and delta neutrophil index (<jats:styled-content style=\"fixed-case\">DNI<\/jats:styled-content>), indicated the presence of immature and possibly abnormal cell populations in white blood cell population. The purpose of this study was to investigate the laboratory performance for discrimination of acute promyelocytic leukemia (<jats:styled-content style=\"fixed-case\">APL<\/jats:styled-content>) cells from other types of leukemia cells and clinical value of <jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DNI<\/jats:styled-content> parameters in bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) samples of patients with acute leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 73 <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> samples of patients with various type of acute leukemia were analyzed. <jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DNI<\/jats:styled-content> parameters were determined by an automated hematology analyzer (ADVIA 120; Siemens Healthcare Diagnostics, New York, NY, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>). Statistical analysis was performed using Kruskal\u2013Wallis and Mann\u2013Whitney <jats:italic>U<\/jats:italic> methods. Receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analysis, survival analysis, and Cox proportional hazard model were used to evaluate the clinical implication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) between <jats:styled-content style=\"fixed-case\">APL<\/jats:styled-content> group and other group in the <jats:styled-content style=\"fixed-case\">DNI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content> values except for <jats:styled-content style=\"fixed-case\">DNI<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">APL<\/jats:styled-content> group and non\u2010<jats:styled-content style=\"fixed-case\">APL<\/jats:styled-content> myeloid leukemia group. The area under curve of <jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content> was larger than that of <jats:styled-content style=\"fixed-case\">DNI<\/jats:styled-content> from the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis for discrimination between <jats:styled-content style=\"fixed-case\">APL<\/jats:styled-content> group and other group. High <jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content> value was associated with the increased risk of adverse outcomes and the worse overall survival in patients with acute leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Delta neutrophil index and <jats:styled-content style=\"fixed-case\">LUC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> showed discriminating power of <jats:styled-content style=\"fixed-case\">APL<\/jats:styled-content> cells from other leukemia cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12183","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T17:03:54Z","timestamp":1389373434000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Application of bone marrow samples for discrimination of acute promyelocytic leukemia from other types of acute leukemia using the routine automated hematology analyzer"],"prefix":"10.1111","volume":"36","author":[{"given":"M. J.","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Kim","sequence":"additional","affiliation":[{"name":"Environmental Health Center for Childhood Leukemia and Cancer Chonnam National University Hwasun Hospital Hwasun Korea"},{"name":"Brain Korea 21 Plus Project Chonnam National University Medical School Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"Ryang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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