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The Clinical and Laboratory Standards Institute (CLSI) published its first LA guideline in 2014. Cross\u2010panel agreement exists on sample manipulation, use of <jats:styled-content style=\"fixed-case\">dRVVT<\/jats:styled-content> analysis, conversion of clotting times to ratios, calculations to demonstrate phospholipid dependence, mixing test interpretation and provision of interpretive reporting. Whilst ISTH restricts assay choice to just <jats:styled-content style=\"fixed-case\">dRVVT<\/jats:styled-content> and activated partial thromboplastin time, BCSH and CLSI consider the case for additional tests. All panels acknowledge the potential for false\u2010negative mixing tests, yet they remain mandated by ISTH and BCSH, the latter, however, indicating that a negative mixing test need not exclude a LA if testing on undiluted plasma is unequivocal. CLSI reprioritizes test order to screen\u2010confirm\u2010mix to reduce false\u2010negative reporting when antibodies are diluted to undetectable levels in mixing tests. Recommendations differ on how to derive cut\u2010off levels, particularly in view of the realities of relatively low donor numbers. Each guideline considers testing of anticoagulated patients, BCSH and CLSI endorsing Taipan snake venom time as a useful supplementary assay in patients on vitamin K antagonists. Although full consensus is not apparent, these publications represent significant moves towards engendering common practices.<\/jats:p>","DOI":"10.1111\/ijlh.12227","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T09:38:30Z","timestamp":1397900310000},"page":"364-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Commonalities and contrasts in recent guidelines for lupus anticoagulant detection"],"prefix":"10.1111","volume":"36","author":[{"given":"G. 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