{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:40:40Z","timestamp":1762875640583},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":288,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Summary<\/jats:title>Introduction<\/jats:title>Cardiovascular disease and thrombotic events have emerged as major causes of mortality in people living with HIV<\/jats:styled-content>. Activated platelets play a key role in both inflammation and thrombosis. Haematology analysers measure a variety of platelet indices, which could be surrogate markers of platelet activation. Flow cytometry offers the discrimination of platelet subpopulations and evaluation of the activation status of platelets. This study aimed to measure platelet indices in untreated HIV<\/jats:styled-content> infection and to evaluate their relationship with markers of immune activation and disease progression.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>One hundred and eighty\u2010five antiretroviral therapy (ART<\/jats:styled-content>)\u2010na\u00efve HIV<\/jats:styled-content>\u2010infected and 145 HIV<\/jats:styled-content>\u2010negative healthy individuals were recruited. Platelet indices measured using the ADVIA<\/jats:styled-content> 2120 platform consisted of platelet count (PLT<\/jats:styled-content> \u00d7109<\/jats:sup>\/L), mean platelet volume (MPV<\/jats:styled-content> fL), platelet distribution width (PDW<\/jats:styled-content>%) and plateletcrit (PCT<\/jats:styled-content>%). These were correlated with CD<\/jats:styled-content>4 count, %CD<\/jats:styled-content>38 on CD<\/jats:styled-content>8+ (CD<\/jats:styled-content>38\/8) T cells, viral load, fibrinogen, D\u2010dimers and CD<\/jats:styled-content>31+ platelet CD<\/jats:styled-content>62P and CD<\/jats:styled-content>36 expression, determined using flow cytometry.<\/jats:p><\/jats:sec>Results<\/jats:title>The HIV<\/jats:styled-content> group had decreased MPV<\/jats:styled-content> levels [median 7.7 (7.1\u20138.3) vs<\/jats:italic>. control group 8.4 (7.8\u20139.2), P<\/jats:italic>\u00a0<\u00a00.0001], which correlated with PCT<\/jats:styled-content>% (r<\/jats:italic>\u00a0=\u00a00.3038, P<\/jats:italic>\u00a0=\u00a00.0013), viral load (r<\/jats:italic>\u00a0=\u00a00.2680, P<\/jats:italic>\u00a0=\u00a00.0177) and PDW<\/jats:styled-content>% (r<\/jats:italic>\u00a0=\u00a00.2479, P<\/jats:italic>\u00a0=\u00a00.0257). Additionally, the MPV<\/jats:styled-content> correlated with CD<\/jats:styled-content>4 count r<\/jats:italic>\u00a0=\u00a0\u22120.2898, P<\/jats:italic>\u00a0=\u00a00.0075. The HIV<\/jats:styled-content> group had decreased PDW<\/jats:styled-content>%, 49.35 (46.40\u201352.65) vs<\/jats:italic>. control group, 53.90 (50\u201356.80), P<\/jats:italic>\u00a0=\u00a00.0170. In addition, the PDW<\/jats:styled-content>% showed correlations with D\u2010dimers (r<\/jats:italic>\u00a0=\u00a00.443, P<\/jats:italic>\u00a0=\u00a00.03) and %CD<\/jats:styled-content>36 (r<\/jats:italic>\u00a0=\u00a0\u22120.3666, P<\/jats:italic>\u00a0=\u00a00.0463).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Platelet indices may offer a rapid and affordable method for monitoring platelet activation and disease progression in patients with HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12307","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T12:18:41Z","timestamp":1416226721000},"page":"450-458","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The evaluation of platelet indices and markers of inflammation, coagulation and disease progression in treatment\u2010na\u00efve, asymptomatic HIV<\/scp>\u2010infected individuals"],"prefix":"10.1111","volume":"37","author":[{"given":"B. 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