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The molecular regulation of the process is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a meta\u2010analysis of 10 previous studies and experimentally probed for a direct action of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> on red blood cells (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>s) by different methods including determination of a microscopic aggregation index, Ca<jats:sup>2+<\/jats:sup> imaging and analysis of sedimentation experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The meta\u2010analysis revealed a statistically significant correlation (Pearson coefficient of 0.37; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), but we could not find any experimental evidence for a direct <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> interaction. Instead, we could confirm a correlation between fibrinogen level and <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, we concluded that <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> cannot account for nor replace each other as a diagnostic measure. The correlation between <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> level and <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> is most probably caused by fibrinogen, because its increase coincides with elevated <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12313","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T10:44:05Z","timestamp":1415616245000},"page":"474-482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Is there a role of <scp>C<\/scp>\u2010reactive protein in red blood cell aggregation?"],"prefix":"10.1111","volume":"37","author":[{"given":"D.","family":"Flormann","sequence":"first","affiliation":[{"name":"Experimental Physics Saarland University Saarbr\u00fccken 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