{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:02:57Z","timestamp":1791198177336,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T00:00:00Z","timestamp":1427932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":152,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic myeloid leukemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) is caused by reciprocal translocation in hematopoietic stem cells (<jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s). This translocation forms the <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> oncogene, which alters several signaling pathways that control malignancy. <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> has three phases: chronic, accelerated, and blast crisis. The micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s or miRs) are noncoding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that downregulate their target gene by targeting 3\u2032 <jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> or through translational inhibition. It has been shown that mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s regulate many biological processes, and dysregulation of these regulatory <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s is involved in disease development, particularly in cancer. The important role of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s as therapeutic agents and biomarkers has been demonstrated in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients at different phases of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stem\u2010loop reverse transcription polymerase chain reaction was used to characterize differentially expressed mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s of leukocytes in the peripheral blood of 50 newly diagnosed <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients in chronic phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Some onco\u2010mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were found to be downregulated (miR\u2010155 and miR\u2010106), and some tumor suppressor miRs (miR\u201016\u20101, miR\u201015a, miR\u2010101, miR\u2010568) were upregulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results show that very few mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s alone would be good candidates for <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> diagnosis independently of conflicting results, but together could be an additional tool for <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> diagnosis. Moreover, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s might be good candidates for prognosis prediction and <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12351","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T22:12:25Z","timestamp":1428012745000},"page":"560-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Expression pattern of key micro<scp>RNA<\/scp>s in patients with newly diagnosed chronic myeloid leukemia in chronic phase"],"prefix":"10.1111","volume":"37","author":[{"given":"P.","family":"Fallah","sequence":"first","affiliation":[{"name":"Blood Transfusion Research center High institute for Research and Education in Transfusion Medicine Tehran Iran"},{"name":"Alborz University of Medical Science Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Amirizadeh","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research center High institute for Research and Education in Transfusion Medicine Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Poopak","sequence":"additional","affiliation":[{"name":"Medical science branch Islamic Azad University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Toogeh","sequence":"additional","affiliation":[{"name":"Thrombosis and Homeostasis Research Center Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Arefian","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Biology College of Science University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kohram","sequence":"additional","affiliation":[{"name":"Department of Biology Cell Molecular and Structural Biology Program Miami University Oxford OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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