{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T05:39:24Z","timestamp":1708148364104},"reference-count":62,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":123,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The classical myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s) consist of chronic myelogenous leukemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) and the non\u2010<jats:styled-content style=\"fixed-case\">CML MPN<\/jats:styled-content>s, polycythemia vera (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>), essential thrombocythemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>), and primary myelofibrosis (<jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content>). Molecular testing plays a crucial role in each of these disease entities. In this review, we discuss the role and caveats of <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> fusion transcript evaluation in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> diagnosis and monitoring, as well as <jats:italic><jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> kinase mutation testing in the setting of tyrosine kinase inhibitor resistance. We also focus on <jats:italic><jats:styled-content style=\"fixed-case\">JAK<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">MPL<\/jats:styled-content>,<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CALR<\/jats:styled-content><\/jats:italic> mutations in <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ET<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PMF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ijlh.12353","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T04:33:00Z","timestamp":1431664380000},"page":"61-71","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular genetic evaluation of myeloproliferative neoplasms"],"prefix":"10.1111","volume":"37","author":[{"given":"E. M.","family":"Azzato","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bagg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"issue":"13","key":"e_1_2_6_3_1","first-page":"62120","article-title":"Chronic myeloid leukaemia","volume":"0140","author":"Apperley JF","year":"2014","journal-title":"Lancet"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-326843"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.116"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2013.835573"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0508-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2014.34.167"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-163485"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403136"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2009.080150"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01236.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030513"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.217"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-291641"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501569"},{"key":"e_1_2_6_17_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology: Chronic Myelogenous Leukemia Version 1.2015 [Internet]","author":"National Comprehensive Cancer Network","year":"2014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.6565"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.104"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.85"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106250"},{"key":"e_1_2_6_22_1","first-page":"502","article-title":"Sequencing treatment in chronic myeloid leukemia: the first choice may be the hardest","volume":"12","author":"Heaney ML","year":"2014","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.9020"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.0904"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.38"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.3619"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-326405"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393041"},{"key":"e_1_2_6_30_1","article-title":"Next\u2010generation deep sequencing improves detection of BCR\u2010ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase","author":"Machova Polakova K","year":"2014","journal-title":"J Cancer Res Clin Oncol"},{"key":"e_1_2_6_31_1","first-page":"501","article-title":"Laboratory tools for diagnosis and monitoring response in patients with chronic myeloid leukemia","volume":"14","author":"Tohami T","year":"2012","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25717"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.09.028"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000013"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200804"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.229"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1988-6"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620710394474"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.220"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.08.005"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-131664"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311347"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312542"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-585141"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-579136"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.3"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1235-2"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2014.07.001"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-12"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32835d82fe"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.35"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1015124"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23895"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12099"},{"key":"e_1_2_6_55_1","first-page":"1194","article-title":"Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis","volume":"89","author":"Mossuz P","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201822"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00960.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2009.07.005"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2013.48.2.128"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515676"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.076901"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-529990"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23384"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12353","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:13:25Z","timestamp":1694646805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":62,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/ijlh.12353"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12353","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"2015-05-14","name":"published_online","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]}}