{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:15:26Z","timestamp":1695492926017},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":104,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IgM multiple myeloma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) is a rare subtype of myeloma that shares clinical and pathological features with Waldenstr\u00f6m's macroglobulinaemia. These are two separate entities that differ both in therapy and prognosis. We report a 57\u2010year\u2010old male, who presented with anaemia, hypercalcaemia, acute renal failure and several vertebral fractures that clinically suggested a multiple myeloma. Further investigations revealed a serum monoclonal component of IgM lambda type and a bone marrow infiltrated by small, lymphoplasmocytic cells. IgM <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> was finally diagnosed by means of both inmunophenotypic and immunohistochemistry techniques, stressing the importance of inmunophenotypic evaluation when clinical and morphological features are discordant. Fluorescence in\u00a0situ hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) studies disclosed a particular combination of deletion 13q14, t(11;14) and monoallelic deletion C\u2010<jats:styled-content style=\"fixed-case\">MAF<\/jats:styled-content> without t(14;16). The clinical evolution after a Bortezomib\u2010containing polychemotherapy and autologous stem cell transplantation (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>) conditioned with busulphan and melphalan is also presented. This very uncommon case highlights the impact of immunophenotyping on the differential diagnosis between IgM <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>, to choose the best treatment and establish an appropriate outcome.<\/jats:p>","DOI":"10.1111\/ijlh.12385","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T14:57:09Z","timestamp":1432133829000},"page":"686-689","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atypical IgM multiple myeloma with deletion of c\u2010<scp>MAF<\/scp>"],"prefix":"10.1111","volume":"37","author":[{"given":"L. M.","family":"Ju\u00e1rez Salcedo","sequence":"first","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"L\u00f3pez Rubio","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Gil Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Garcia\u2010Suarez","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Magro","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Arranz","sequence":"additional","affiliation":[{"name":"Division of Cytogenetic Hospital Universitario La Princesa Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Guti\u00e9rrez Jomarr\u00f3n","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Marcellini Antonio","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Blasco","sequence":"additional","affiliation":[{"name":"Division of Pathological Anatomy Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Burgaleta","sequence":"additional","affiliation":[{"name":"Division of Hematology Hospital Universitario Pr\u00edncipe de Asturias Madrid Spain"},{"name":"Medicine Departament Universidad de Alcal\u00e1 de Henares Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21845"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06969.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.11.002"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65225-2"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/75.1.1"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP0N7IELYUNJGZ"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11080"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040410"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.06.020"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22067"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21845"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2436"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3735"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.174"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2006.00837.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1182\/blood.V91.12.4457.412k48_4457_4463","article-title":"Frequent dysregulation of the C\u2010MAF proto oncogen at 16q23 by translocation to an Ig locus in multuple mieloma","volume":"91","author":"Chesi M","year":"1998","journal-title":"Blood"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(04)00019-4"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.67"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12385","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:56:18Z","timestamp":1695491778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,20]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/ijlh.12385"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12385","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,20]]}}}