{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:03Z","timestamp":1792173363087,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T00:00:00Z","timestamp":1442016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      D\u2010dimer assay, generally evaluated according to cutoff points calibrated for\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      exclusion, is used to estimate the individual risk of recurrence after a first idiopathic event of venous thromboembolism (\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Commercial\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      \u2010dimer assays, evaluated according to predetermined cutoff levels for each assay, specific for age (lower in subjects &lt;70\u00a0years) and gender (lower in males), were used in the recent\n                      <jats:styled-content style=\"fixed-case\">DULCIS<\/jats:styled-content>\n                      study. The present analysis compared the results obtained in the\n                      <jats:styled-content style=\"fixed-case\">DULCIS<\/jats:styled-content>\n                      with those that might have been had using the following different cutoff criteria: traditional cutoff for\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      exclusion, higher levels in subjects aged \u226560\u00a0years, or age multiplied by 10.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In young subjects, the\n                      <jats:styled-content style=\"fixed-case\">DULCIS<\/jats:styled-content>\n                      low cutoff levels resulted in half the recurrent events that would have occurred using the other criteria. In elderly patients, the\n                      <jats:styled-content style=\"fixed-case\">DULCIS<\/jats:styled-content>\n                      results were similar to those calculated for the two age\u2010adjusted criteria. The adoption of traditional\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      exclusion criteria would have led to positive results in the large majority of elderly subjects, without a significant reduction in the rate of recurrent event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The results confirm the usefulness of the cutoff levels used in\n                      <jats:styled-content style=\"fixed-case\">DULCIS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.12426","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T04:51:01Z","timestamp":1442033461000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":585,"title":["Comparison between different\n                    <scp>D<\/scp>\n                    \u2010\n                    <scp>D<\/scp>\n                    imer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the\n                    <scp>DULCIS<\/scp>\n                    study"],"prefix":"10.1111","volume":"38","author":[{"given":"G.","family":"Palareti","sequence":"first","affiliation":[{"name":"Italian Association of Anticoagulated Patients Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Legnani","sequence":"additional","affiliation":[{"name":"Angiology and Blood Coagulation 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