{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:21:36Z","timestamp":1788067296828,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T00:00:00Z","timestamp":1443225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The automated <jats:styled-content style=\"fixed-case\">XN<\/jats:styled-content>\u20101000 hematology analyzer enables to perform a blood cell count and a leukocyte differential. When abnormal cells were detected, a flag was generated by the analyzer and a manual microscopic examination of the corresponding blood film was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the white blood cell differentials provided by the automated hematology analyzer <jats:styled-content style=\"fixed-case\">XN<\/jats:styled-content>\u20101000 in a pediatric population (<jats:italic>n<\/jats:italic> = 765) with those obtained through microscopic examination by cytologists and those obtained using a previous version of this analyzer, the <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>\u20102100. Leukocytes count as well as flags sensitivity and specificity was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The leukocytes count provided by the analyzer is in good accordance with the differential obtained by manual count in children older than 3 months. The sensitivity for blast detection is 99% and the detection of reactive cells is 63%. The flag specificity remains low (&lt;35%) for blood samples collected from infants between 8 days and 2 years of age, but increases up to 67% thereafter. The results obtained with the <jats:styled-content style=\"fixed-case\">XN<\/jats:styled-content>\u20101000 analyzer show an improvement in comparison with those obtained with the <jats:styled-content style=\"fixed-case\">XE<\/jats:styled-content>\u20102100 analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The automated <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> differential provided by the <jats:styled-content style=\"fixed-case\">XN<\/jats:styled-content>\u20101000 analyzer in the pediatric setting is accurate, but a meticulous microscopic examination of blood smears remains necessary for infants up to 3 months of age to validate the analyzer flags.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12436","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T05:59:47Z","timestamp":1443247187000},"page":"54-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Performance evaluation of the Sysmex <scp>XN<\/scp>\u20101000 hematology analyzer in assessment of the white blood cell count differential in pediatric specimens"],"prefix":"10.1111","volume":"38","author":[{"given":"P.\u2010H.","family":"Becker","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique H\u00f4pital R. 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