{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:00Z","timestamp":1740147240587,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3\u20100289"],"award-info":[{"award-number":["P3\u20100289"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P3-0289"],"award-info":[{"award-number":["P3-0289"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Monoclonal B\u2010cell lymphocytosis (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) is a premalignant asymptomatic condition characterized by the presence of a small population of monoclonal B lymphocytes (less than 5 \u00d7 10<jats:sup>9<\/jats:sup>\/L) in the venous blood of otherwise healthy individuals. Incidence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> is higher among first\u2010degree relatives of patients with chronic lymphocytic leukemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) and also increases with age and among men. We compared the incidence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> found in the same environment in both an open general population and relatives of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples were analyzed with 5\u2010parameter flow cytometry using following monoclonal antibodies: kappa and lambda clonality, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20. We analyzed 216 samples of patients in the Slovenian area of Lower Carniola aged 23\u201388 years. Fifty\u2010four patients who came from families where <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> is present were compared by age and gender to 162 healthy individuals from the general population of the same region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 10 cases of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> (4.6%). In 9.4% of younger (\u2264 50 years) first\u2010degree relatives of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients with immunophenotypic characteristics of atypical <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>, we observed a prevailingly normal \u03ba to \u03bb ratio. The difference in incidence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> cases between relatives and the general population decreases with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> in Slovenia can be coincidentally found with a similar frequency to previously studied populations of other parts of Europe. We found, however, a higher incidence of atypical <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> among first\u2010degree relatives.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12488","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:36:01Z","timestamp":1460313361000},"page":"341-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monoclonal B\u2010cell lymphocytosis in the population of Slovenian region of Lower Carniola"],"prefix":"10.1111","volume":"38","author":[{"given":"P.","family":"Bajuk","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Furlan","sequence":"additional","affiliation":[{"name":"Department of Haematology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"\u010cernel\u010d","sequence":"additional","affiliation":[{"name":"Department of Haematology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"\u010ceh","sequence":"additional","affiliation":[{"name":"General Hospital Novo Mesto Novo Mesto Slovenija"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Podgornik","sequence":"additional","affiliation":[{"name":"Department of Haematology University Medical Centre Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1007\/s11899-012-0144-z"},{"key":"e_1_2_6_3_1","first-page":"163","article-title":"Monoclonal b\u2010cell lymphocytosis (MB\u2010L)","volume":"3","author":"Rawstron AC","year":"2010","journal-title":"Kasim"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1038\/leu.2009.287"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1111\/j.1365-2141.2005.05550.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.5858\/arpa.2011-0696-OA"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1038\/leu.2012.187"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1182\/blood-2012-01-404681"},{"key":"e_1_2_6_9_1","first-page":"720","article-title":"Monoclonal B\u2010Cell Lymphocytosis: Update on Diagnosis, Clinical Outcome, and Counseling","volume":"11","author":"Parikh SA","year":"2013","journal-title":"Clin Adv Hematol Oncol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1002\/cyto.b.20538"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1111\/j.1365-2141.2007.06865.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1182\/blood-2008-09-176933"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1309\/AJCPPHSUQM8XBJH7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1590\/S1516-31802011000300008"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1371\/journal.pone.0067751"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1182\/blood-2013-08-523704"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1111\/j.1365-2141.2010.08339.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1038\/sj.leu.2404116"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1056\/NEJMoa0806122"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1056\/NEJMoa075290"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1200\/JCO.2008.21.2704"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12488","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:57:37Z","timestamp":1695556657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ijlh.12488"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12488","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"type":"print","value":"1751-5521"},{"type":"electronic","value":"1751-553X"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}