{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:49:08Z","timestamp":1764510548321},"reference-count":35,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Since the publication of the latest World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) classification in 2008, there has been a significant effort for clarification of unresolved questions, especially with the help of the rapidly developing field of molecular genetic studies, next\u2010generation sequencing in particular. Numerous entities within the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> categories of myeloproliferative neoplasms (<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content>s) and myelodysplastic (MDS)\/MPNs have been extensively studied, with large published series attempting to characterize and better define their morphologic and molecular genetic features. This emerging genetic landscape maintains a robust correlation with the various disease entities recognized by the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> classification scheme based on a careful integration of detailed clinical information, bone marrow and peripheral blood morphology, immunohistology, and genomics. This brief review summarizes the current guidelines as they apply to diagnosing both the classical <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> negative <jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> (polycythemia vera, essential thrombocythemia, and primary myelofibrosis) and the more common subtypes of <jats:styled-content style=\"fixed-case\">MDS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MPN<\/jats:styled-content> overlap syndromes. The more important recent molecular updates as well as the upcoming changes to the current <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> classification, expected to be published in late 2016, will also be briefly reviewed.<\/jats:p>","DOI":"10.1111\/ijlh.12509","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T05:03:28Z","timestamp":1462856608000},"page":"12-19","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Myeloproliferative neoplasms (<i><scp>BCR<\/scp>\u2010<scp>ABL<\/scp>1<\/i> negative) and myelodysplastic\/myeloproliferative neoplasms: current diagnostic\u00a0principles and upcoming updates"],"prefix":"10.1111","volume":"38","author":[{"given":"J. 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