{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:24:55Z","timestamp":1745238295133},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study, we aimed to evaluate Red blood cell distribution width (RDW) in patients with acute rheumatic carditis during the acute phase and after anti\u2010inflammatory therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients diagnosed with acute rheumatic carditis (<jats:styled-content style=\"fixed-case\">ARC<\/jats:styled-content>) between 2006 and 2014 and age\u2010 and sex\u2010matched controls were retrospectively analyzed. At the time of diagnosis and after 2 months of medical therapy, we reviewed the obtained demographic features; echocardiographic data; complete blood count reports, including RDW; acute phase reactants, including C\u2010reactive protein; and erythrocyte sedimentation rate values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of the cases with <jats:styled-content style=\"fixed-case\">ARC<\/jats:styled-content> and age\u2010 and sex\u2010matched controls were 100 and 110, respectively. The mean age of patients was 11.6 \u00b1 2.5 years. <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> and platelet counts, <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> were found to be significantly higher in patient group compared with controls at the time of diagnosis, prior to the onset of treatment. <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>, platelet count, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">ESR<\/jats:styled-content> levels significantly decreased after an 8 weeks of medical treatment. <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> values after the medical treatment were still significantly higher compared with controls. <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> values were significantly higher in patients with multiple valvular involvement both prior to and after the treatment. Moreover, we found a significant and positive correlation between the <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> and the severity of mitral regurgitation in our patients (<jats:italic>r<\/jats:italic>: 0.46, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High levels of <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> after initial medical treatment may indicate an ongoing subtle inflammatory process that leads to future stenotic valvular lesions. However, long\u2010term follow\u2010up studies are needed involving adulthood period to support this hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12544","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T10:35:33Z","timestamp":1469010933000},"page":"569-575","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Red blood cell distribution width: can it be a predictive marker for long\u2010term valvular involvement in children with acute rheumatic carditis?"],"prefix":"10.1111","volume":"38","author":[{"given":"M.","family":"Kucuk","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Karadeniz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Celegen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Demirol","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Izmir Dr. Behcet Uz Children's Hospital Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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