{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:49:46Z","timestamp":1792507786639,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prognostic value of serum ferritin level in patients with peripheral T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>) remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed clinical data from 78 consecutive patients with newly diagnosed <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> that were treated with anthracycline\u2010containing regimens between 1998 and 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients consisted of 50 males and 28 females with a median age of 64 years (range, 16\u201383 years). The subtypes of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> were 39 <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>, not otherwise specified and 39 angioimmunoblastic T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">AITL<\/jats:styled-content>). The median observation period for the surviving patients was 50 months. The overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was poorer in patients with serum ferritin level above the upper normal limit (<jats:italic>n<\/jats:italic> = 28), compared with patients with serum ferritin level within normal range (<jats:italic>n<\/jats:italic> = 50; 4\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>: 23% <jats:italic>vs<\/jats:italic>. 72%; <jats:italic>P<\/jats:italic> &lt; 0.001). In the multivariate analysis, poor performance status (<jats:italic>P<\/jats:italic> = 0.006) and elevated serum ferritin level (<jats:italic>P<\/jats:italic> = 0.018) were independent risk factors for poor <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum ferritin level is a useful prognostic marker for <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12592","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T04:26:49Z","timestamp":1480048009000},"page":"112-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Serum ferritin level is a prognostic marker in patients with peripheral T\u2010cell lymphoma"],"prefix":"10.1111","volume":"39","author":[{"given":"S.","family":"Koyama","sequence":"first","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Saiseikai Yokohama Nanbu Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Motohashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Immunology Fujisawa City Hospital Fujisawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Yamato Municipal Hospital Yamato Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Koharazawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Yamato Municipal Hospital Yamato Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yokohama Ekisaikai Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Motomura","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3080"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq359"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00323.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg493"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0426-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860115)57:2<305::AID-CNCR2820570219>3.0.CO;2-D"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.09.008"},{"key":"e_1_2_6_11_1","first-page":"102","article-title":"Serum ferritin\u2013a tumor marker in malignant lymphomas?","volume":"13","author":"Aulbert E","year":"1990","journal-title":"Onkologie"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1976.138"},{"key":"e_1_2_6_13_1","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA)","volume":"92","author":"Gisselbrecht C","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2136"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4515"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2013.07.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0149-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1644-6"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:06:41Z","timestamp":1695510401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,24]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/ijlh.12592"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12592","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,24]]}}}