{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:33:36Z","timestamp":1771331616610,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T00:00:00Z","timestamp":1482624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T00:00:00Z","timestamp":1482624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T00:00:00Z","timestamp":1482624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We previously reported that granulocyte colony\u2010stimulating factor (G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) plays a critical role in ovulation, suggesting that neutrophils may maintain ovulation. We assessed myeloperoxidase (MPO), a major and specific enzyme of neutrophils, in women with abnormal and normal menstrual cycles to clarify the relationship between MPO and ovulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed MPO activity in blood neutrophils of women with abnormal menstrual cycles (indicative of anovulation, <jats:italic>n<\/jats:italic> = 12) and age\u2010 and body mass index\u2010matched normal menstrual cycles (indicative of ovulation, <jats:italic>n<\/jats:italic> = 24) using two parameters as a marker of MPO, Neut X and mean peroxidase index (<jats:styled-content style=\"fixed-case\">MPXI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MPO of women with abnormal menstrual cycles was significantly lower than that of women with normal menstrual cycles [Neut X: 62.6 \u00b1 1.1 (mean \u00b1 standard error of the mean) <jats:italic>vs<\/jats:italic>. 66.2 \u00b1 0.3, <jats:italic>P<\/jats:italic> = 0.009; <jats:styled-content style=\"fixed-case\">MPXI<\/jats:styled-content>: \u22120.54 \u00b1 1.66 <jats:italic>vs<\/jats:italic>. 4.91 \u00b1 0.53, <jats:italic>P<\/jats:italic> = 0.008]. Among women with normal menstrual cycles, MPO was highest in the follicular phase (Neut X: 67.0 \u00b1 0.3; <jats:italic>P<\/jats:italic> = 0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The difference in MPO between women with abnormal and normal menstrual cycles and the upregulation of MPO before ovulation suggest that neutrophils and MPO are closely related to ovulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12599","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T15:42:51Z","timestamp":1482680571000},"page":"169-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myeloperoxidase in blood neutrophils during normal and abnormal menstrual cycles in women of reproductive age"],"prefix":"10.1111","volume":"39","author":[{"given":"T.","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Osaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Neyatani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Central Clinical Laboratory Kanazawa Medical University Hospital Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Central Clinical Laboratory Kanazawa Medical University Hospital Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Central Clinical Laboratory Kanazawa Medical University Hospital Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sasagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod22.1.73"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56581-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00009-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1999.tb00103.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0990561"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.12.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-845-4_1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.10.3503"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0712349"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1994.tb00431.x"},{"key":"e_1_2_8_12_1","first-page":"474","article-title":"Induced myeloperoxidase activity and related superoxide inhibition during hormone replacement therapy","volume":"108","author":"B\u00e9k\u00e9si G","year":"2001","journal-title":"BJOG"},{"key":"e_1_2_8_13_1","unstructured":"Welt CK. 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