{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:35:13Z","timestamp":1792100113028,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T00:00:00Z","timestamp":1482969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Department of Biotechnology India","award":["BT\/COE\/34\/SP13432\/2015."],"award-info":[{"award-number":["BT\/COE\/34\/SP13432\/2015."]}]},{"name":"Wellcome DBT India Alliance","award":["IA\/S\/11\/2500267"],"award-info":[{"award-number":["IA\/S\/11\/2500267"]}]},{"name":"Wellcome DBT India Alliance","award":["IA\/S\/15\/1\/501842"],"award-info":[{"award-number":["IA\/S\/15\/1\/501842"]}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The hallmark of chronic myeloid leukemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) is the presence of Philadelphia chromosome, its resultant fusion transcript (<jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic>), and fusion protein (p210). Alternate breakpoints in <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content><\/jats:italic> (m\u2010bcr, \u03bc\u2010bcr, and others) or <jats:italic><jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> result in the expression of few rare fusion transcripts (e19a2, e1a2, e13a3, e14a3) and fusion proteins (p190, p200, p225) whose exact clinical significance remains to be determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study was designed to determine the type and frequency of <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> fusion transcripts in 1260 <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients and to analyze the prognosis and treatment response in patients harboring rare <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> fusion transcripts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of various <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> fusion transcripts was as follows: e14a2 (60%), e13a2 (34.3%), e1a2 (1.2%), e1a2 + e13a2 (2.0%), e1a2 + e14a2 (1.8%), e19a2 (0.3%), and e14a3 (0.3%). <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients with e1a2 transcripts had higher rates of disease progression, resistance, or suboptimal response to imatinib and failed to achieve major molecular response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Characterization of the specific fusion transcript in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients is important owing to the difference in prognosis and response to therapy in addition to the conventional need for monitoring treatment response. <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients with e1a2 transcripts have to be closely monitored due to the high incidence of disease progression and treatment resistance\/failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12616","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T04:22:45Z","timestamp":1483071765000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Frequency of rare <i><scp>BCR<\/scp>\u2010<scp>ABL<\/scp>1<\/i> fusion transcripts in chronic myeloid leukemia patients"],"prefix":"10.1111","volume":"39","author":[{"given":"A. K.","family":"Arun","sequence":"first","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Senthamizhselvi","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vinodhini","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"Janet","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Cytogenetics Unit Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/243290a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2408149"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2375.bloodjournal8872375"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144790"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3460176"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90450-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.41.1183"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1182\/blood.V88.7.2410.bloodjournal8872410","article-title":"Neutrophilic chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR\/ABL with C3\/A2 junction)","volume":"88","author":"Pane F","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0930"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1037751"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500138138"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(97)80003-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01640.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1182\/blood.V89.7.2602","article-title":"Detection of bcrabl transcripts in Philadelphia chromosome\u2010positive acute lymphoblastic leukemia after marrow transplantation","volume":"89","author":"Radich J","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03669"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.009134"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.096537"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401592"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403136"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190903332486"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-204693"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.07.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05119.x"},{"key":"e_1_2_7_25_1","first-page":"247","article-title":"Frequency of BCR\u2010ABL Fusion Transcripts in Iranian Patients with Chronic Myeloid Leukemia","volume":"11","author":"Yaghmaie M","year":"2008","journal-title":"Arch Iranian Med"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572010005000037"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-319038"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-234666"},{"key":"e_1_2_7_29_1","first-page":"BR193","article-title":"Relationship of the BCR gene breakpoint and the type of BCR\/ABL transcript to clinical course, prognostic indexes and survival in patients with chronic myeloid leukemia","volume":"8","author":"Prejzner W","year":"2002","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_30_1","first-page":"839","article-title":"The location of the Philadelphia chromosomal breakpoint site and prognosis in chronic granulocytic leukemia","volume":"4","author":"Tefferi A","year":"1990","journal-title":"Leukemia"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-674242"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.6026\/97320630010108"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1182\/blood.V89.11.4239","article-title":"A new case of chronic myeloid leukemia with c3\/a2 BCR\/ABL junction. Is it really a distinct disease?","volume":"89","author":"Macro M","year":"1997","journal-title":"Blood"},{"key":"e_1_2_7_34_1","first-page":"320","article-title":"p230 does not always predict a mild clinical course in myeloid malignancies: e19a2 bcr\/abl fusion transcript with additional chromosome abnormalities in a patient with acute monoblastic leukemia (M5a)","volume":"86","author":"Bernasconi P","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.01098.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2009.090008"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000029678"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400913"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.12.4019"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12616","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:47:44Z","timestamp":1695559664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,29]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/ijlh.12616"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12616","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,29]]}}}