{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:41:50Z","timestamp":1775047310152,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T00:00:00Z","timestamp":1488585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T00:00:00Z","timestamp":1488585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T00:00:00Z","timestamp":1488585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/501100005421","name":"Guilan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005421","name":"Guilan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Considering the high prevalence of glucose\u20106\u2010phosphate dehydrogenase (G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) deficiency among newborns, different screening methods have been established in various countries. In this study, we aimed to assess the prevalence of G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> deficiency among newborns in Rasht, Iran, and compare G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> activity in cord blood samples, using quantitative and qualitative tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional, prospective study was performed at five largest hospitals in Rasht, Guilan Province, Iran. The screening tests were performed for all the newborns, referred to these hospitals. Specimens were characterized in terms of G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> activity under ultraviolet light, using the kinetic method and the qualitative fluorescent spot test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>). We also determined the sensitivity, specificity, negative predictive value, and positive predictive value of the qualitative assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood samples were collected from 1474 newborns. Overall, 757 (51.4%) subjects were male. As the findings revealed, 1376 (93.4%) newborns showed normal G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> activity, while 98 (6.6%) had G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> deficiency. There was a significant difference in the mean G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> level between males and females (<jats:italic>P<\/jats:italic> = 0.0001). Also, a significant relationship was detected between <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> results and the mean values obtained in the quantitative test (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to the present study, <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> showed acceptable sensitivity and specificity for G6<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> activity, although it appeared inefficient for diagnostic purposes in some cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12618","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T11:11:30Z","timestamp":1488625890000},"page":"251-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of quantitative and qualitative tests for glucose\u20106\u2010phosphate dehydrogenase deficiency in the neonatal period"],"prefix":"10.1111","volume":"39","author":[{"given":"F.","family":"Keihanian","sequence":"first","affiliation":[{"name":"Guilan University of Medical Sciences Rasht Iran"},{"name":"Cardiology Department &amp; Pharmaceutical Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Basirjafari","sequence":"additional","affiliation":[{"name":"Guilan University of Medical Sciences Rasht Iran"},{"name":"Radiology Department Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Darbandi","sequence":"additional","affiliation":[{"name":"Pediatrics Growth Disorders Research Centre 17th Shahrivar Hospital School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Saeidinia","sequence":"additional","affiliation":[{"name":"Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jafroodi","sequence":"additional","affiliation":[{"name":"Pediatrics Growth Disorders Research Centre 17th Shahrivar Hospital School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Sharafi","sequence":"additional","affiliation":[{"name":"Pediatrics Growth Disorders Research Centre 17th Shahrivar Hospital School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shakiba","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical science Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"114","article-title":"Glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency [In Persian]","volume":"8","author":"Zahed Pasha Y","year":"2006","journal-title":"J Babol Univ Med Sci"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0490"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/rwgn.2001.1520"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-112"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407826-0.00004-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0099"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.10.007"},{"key":"e_1_2_7_11_1","first-page":"61","article-title":"Prevalence of Glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency of newborns in Rasol Akram and Ali Asghar hospitals of Tehran [In Persian]. 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