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Reference intervals are required to be able to evaluate results in relation to a patients\u2019 hemostatic disorder. This becomes one of the most important tasks conducted in the coagulation laboratory. However, many laboratories lack the time, finances and in many cases the expertise to conduct this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Many <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content> are obtained from package inserts, or from publications written by experts in lieu of laboratories conducting their own studies. An overview of validating reference intervals and options for verifying or transference of reference intervals is discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the confidence interval and the acceptability of risk laboratories are willing to accept, coagulation laboratories have options to conduct robust studies for their <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>. Data mining or global reference studies may help to provide data for age specific ranges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010analytical variables and selection of healthy subjects have the largest impact on coagulation testing outcomes and need to be well controlled during the establishment of reference intervals. Laboratories have options in lieu of conducting a full validation on how to verify <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content> based on smaller <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content> studies or transference of <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content> after determining compatibility of the original <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content> study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12661","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T01:40:49Z","timestamp":1493257249000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Establishing reference intervals in the coagulation laboratory"],"prefix":"10.1111","volume":"39","author":[{"given":"D. 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