{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:06:53Z","timestamp":1787508413705,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Malta"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Summary<\/jats:title>\n \n Introduction<\/jats:title>\n \n Vitamin K antagonist (\n VKA<\/jats:styled-content>\n ) treatment requires routine monitoring using the international normalized ratio (\n INR<\/jats:styled-content>\n ). However, different\n INR<\/jats:styled-content>\n assays may vary in their results. The aim of this study was to assess the agreement of three different\n INR<\/jats:styled-content>\n methods, compared with thrombin generation, in patients on\n VKA<\/jats:styled-content>\n treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Sixty patients attending the Anticoagulation Clinic at Mater Dei Hospital (Msida, Malta) for\n VKA<\/jats:styled-content>\n monitoring between August and September 2015 were enrolled. The\n INR<\/jats:styled-content>\n was tested using a point\u2010of\u2010care (\n POC<\/jats:styled-content>\n ) device (CoaguChek\n XS<\/jats:styled-content>\n Plus, Roche Diagnostics) for both capillary and venous blood samples, a photo\u2010optical (Sysmex\n CS<\/jats:styled-content>\n \u20102100i\/\n CA<\/jats:styled-content>\n \u20101500, Siemens) and a mechanical clot detection system (Thrombolyzer\n XRC<\/jats:styled-content>\n , Behnk Elektronik). All assays used human recombinant thromboplastin as reagent. Thrombin generation was performed using the calibrated automated thrombogram.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was a negative curvilinear correlation between the endogenous thrombin potential and different\n INR<\/jats:styled-content>\n assays (\n r<\/jats:italic>\n \u2264\u2212.75) and a strong positive linear correlation between the CoaguChek\n XS<\/jats:styled-content>\n Plus on capillary samples and the other\n INR<\/jats:styled-content>\n methodologies (\n r<\/jats:italic>\n \u2265.96).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n All different\n INR<\/jats:styled-content>\n assays showed good correlation with the thrombin generation potential. The\n POC INR<\/jats:styled-content>\n showed one of the highest correlation coefficients with thrombin generation, confirming the\n POC<\/jats:styled-content>\n devices as an accurate, valid alternative to laboratory\n INR<\/jats:styled-content>\n in\n VKA<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijlh.12668","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T00:36:57Z","timestamp":1494635817000},"page":"482-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A comparative study using thrombin generation and three different\n INR<\/scp>\n methods in patients on Vitamin K antagonist treatment"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8922-8823","authenticated-orcid":false,"given":"N.","family":"Riva","sequence":"first","affiliation":[{"name":"Department of Pathology University of Malta Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vella","sequence":"additional","affiliation":[{"name":"Coagulation Medicine Laboratory Department of Pathology Mater Dei Hospital Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meli","sequence":"additional","affiliation":[{"name":"Point\u2010of\u2010Care Testing Committee Department of Pathology Mater Dei Hospital Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Sheffield Haemophilia and Thrombosis Centre University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zammit","sequence":"additional","affiliation":[{"name":"Coagulation Medicine Laboratory Department of Pathology Mater Dei Hospital Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Calamatta","sequence":"additional","affiliation":[{"name":"Point\u2010of\u2010Care Testing Committee Department of Pathology Mater Dei Hospital Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Makris","sequence":"additional","affiliation":[{"name":"Sheffield Haemophilia and Thrombosis Centre University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kitchen","sequence":"additional","affiliation":[{"name":"Sheffield Haemophilia and Thrombosis Centre University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Ageno","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-048X","authenticated-orcid":false,"given":"A.","family":"Gatt","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Malta Msida Malta"},{"name":"Coagulation Medicine Laboratory Department of Pathology Mater Dei Hospital Msida Malta"},{"name":"Point\u2010of\u2010Care Testing Committee Department of Pathology Mater Dei Hospital Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2292"},{"key":"e_1_2_8_3_1","first-page":"64","article-title":"Guidelines for Thromboplastins and Plasma Used to Control Anticoagulant Therapy","volume":"889","author":"World Health Organization","year":"1999","journal-title":"WHO Tech Rep Ser"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10900-015-0066-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07267.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283070872"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21497"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.06.037"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/213109"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.08.027"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200249"},{"key":"e_1_2_8_12_1","first-page":"633","article-title":"Monitoring oral anticoagulant treatment from plasma stored for up to 48\u00a0hours and frozen plasma","volume":"84","author":"Grau E","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00775.x"},{"key":"e_1_2_8_14_1","unstructured":"PleschW WolfT.Performance evaluation of the CoaguChek XS Plus System(Study LB 157\u20102005) evaluation report. 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