{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:09:18Z","timestamp":1790251758928,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The osmotic fragility (<jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content>) test was a central test for the diagnosis of hereditary red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) disorders (mostly hereditary spherocytosis (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>), but thalassaemia as well). Nowadays although the traditional multitubes method has lost a prominent place, many laboratories still perform such a laboured test, despite the lack of standardization. In fact, the evaluation of <jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content> may offer an inexpensive screening for <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> disorders. We present a new semi\u2010automatic device, allowing the continuous recording of <jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content>, by an updated dialysis method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Repeatability, stability over time, influence of the anticoagulant were evaluated among a population of healthy blood donors. The test was then performed among patients presenting inherited <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> disorders (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> or haemoglobinopathies) where <jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content> is typically altered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Repeatability was excellent; the parameters were greatly influenced by the nature of the anticoagulant and interestingly appeared stable for 48\u00a0h. Patients with <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> disorders displayed the expected profile in regard with their disease: patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> all presented an increased <jats:styled-content style=\"fixed-case\">OF<\/jats:styled-content> while patients with haemoglobinopathy displayed resistant profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The device offers a substantial improvement in terms of standardization and consistency of the results and may offer a considerable gain for general laboratories.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12683","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T11:59:05Z","timestamp":1494244745000},"page":"521-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of <scp>OSMOCELLS<\/scp>, a new semi\u2010automatic device for osmotic fragility assessment"],"prefix":"10.1111","volume":"39","author":[{"given":"D.","family":"G\u00e9rard","sequence":"first","affiliation":[{"name":"CHRU Nancy Service d'h\u00e9matologie biologique Vandoeuvre les Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010J.","family":"Fattet","sequence":"additional","affiliation":[{"name":"CHRU Nancy Service d'h\u00e9matologie biologique Vandoeuvre les Nancy Nancy France"},{"name":"INSERM U 1116 Vandoeuvre les Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brakta","sequence":"additional","affiliation":[{"name":"CHRU Nancy Service d'h\u00e9matologie biologique Vandoeuvre les Nancy Nancy France"},{"name":"INSERM U 1116 Vandoeuvre les Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Phulpin","sequence":"additional","affiliation":[{"name":"CHRU Nancy Service 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