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However, whether this fusion gene might be used as a reliable marker of minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) following allogeneic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) remains unknown<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of consecutive 29 patients with T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> who received allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> were collected. Their <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> were evaluated by <jats:italic><jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAL<\/jats:styled-content>1,<\/jats:italic> Wilms' tumor 1 (<jats:italic><jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1<\/jats:italic>) expression, and the leukemia\u2010associated immunophenotype (<jats:styled-content style=\"fixed-case\">LAIP<\/jats:styled-content>) .<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up was 354\u00a0days (71\u20102111\u00a0days). Of the enrolled patients, 14 (87.5%) patients died of leukemia relapse. A total of 15 (51.7%) patients experienced relapse at a median of 90\u00a0days (60\u2010540\u00a0days) after transplantation. The <jats:italic><jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAL<\/jats:styled-content>1<\/jats:italic> expression of 16 patients converted from negative prior to transplantation to positive at 77\u00a0days (30\u2010281\u00a0days) following transplantation; furthermore, 15 (93.8%) of them eventually experienced relapse. In the 15 relapsed patients, 13 (86.7%) had increased <jats:italic><jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAL<\/jats:styled-content>1<\/jats:italic> expression levels 30\u00a0days (11\u2010220\u00a0days) earlier than the hematological relapse and the detection of abnormal <jats:italic><jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1<\/jats:italic> and <jats:styled-content style=\"fixed-case\">LAIP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We are the first to demonstrate the reliability of the <jats:italic><jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TAL<\/jats:styled-content>1<\/jats:italic> fusion gene as a good <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> marker for patients with T\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12711","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T05:18:40Z","timestamp":1500873520000},"page":"613-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The clinical significance of monitoring the expression of the <i><scp>SIL<\/scp>\u2010<scp>TAL<\/scp>1<\/i> fusion gene in T\u2010cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-8087","authenticated-orcid":false,"given":"X.","family":"Zhao","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell 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