{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:01:46Z","timestamp":1792076506555,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The identification of aberrancies in leukemia\u2010associated immunophenotype (LAIP) of acute lymphoblastic leukemia (ALL) is quite important in the assessment of minimal residual disease (MRD). This study, the first from Iraq, aimed to assess the frequency and patterns of LAIP among Iraqi patients with ALL, to establish future strategies for evaluating MRD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 282 newly diagnosed Iraqi ALL cases were analyzed with six\u2010parameter flow cytometry using a panel of 29 monoclonal antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunological subtyping revealed that 85.5% of cases were B\u2010ALL and the remainder T\u2010ALL. LAIP was detected in 97.1% of B\u2010ALL, and in 26.8% of T\u2010ALL. The asynchronous maturation\u2010associated antigen patterns in B\u2010ALL were CD10<jats:sup>strong+<\/jats:sup>\/TdT<jats:sup>dim+<\/jats:sup>, CD38<jats:sup>dim+<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup>, CD10<jats:sup>dim+<\/jats:sup>\/CD34<jats:sup>+<\/jats:sup>, CD10<jats:sup>strong<\/jats:sup>\/CD20<jats:sup>strong+<\/jats:sup>, CD20<jats:sup>strong+<\/jats:sup>\/CD34<jats:sup>+,<\/jats:sup> and CD45<jats:sup>dim+<\/jats:sup>\/CD20<jats:sup>strong+<\/jats:sup> in 84.6%, while the cross\u2010lineage myeloid expression was seen in 81.3% and aberrant T\u2010cell antigen expression in 6.2%. For T\u2010ALL, asynchronous maturation\u2010associated antigen patterns included the following: CD1a<jats:sup>+<\/jats:sup>\/CD5<jats:sup>+<\/jats:sup>\/sCD3<jats:sup>+<\/jats:sup> and CD34<jats:sup>+<\/jats:sup>\/sCD3<jats:sup>+<\/jats:sup> in 12.2%. Myeloid and B\u2010cell antigen expression were each identified in 7.3% of T\u2010ALL. No significant differences in LAIP were found between children and adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high rates and the patterns of LAIP particularly in Iraqi B\u2010ALL patients may allow the development of more cost\u2010effective strategies for MRD monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12716","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T11:49:59Z","timestamp":1500464999000},"page":"625-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Immunophenotypic aberrancies in acute lymphoblastic leukemia from 282 Iraqi patients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6025-9802","authenticated-orcid":false,"given":"S. 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