{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:50:57Z","timestamp":1785563457370,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The purpose was to evaluate the analytical performances of Sysmex XN<\/jats:styled-content>\u00a03000 and UniCel DxH 800 comparing the obtained results with manual counting and between each other. Also flagging capabilities of abnormal cells were compared for both analyzers.<\/jats:p><\/jats:sec>Methods<\/jats:title>Two thousand one hundred and forty\u2010two whole\u2010blood samples were analyzed for evaluation. The samples flagged due to blast, atypical lymphocyte (AL<\/jats:styled-content>), immature granulocyte (IG<\/jats:styled-content>), or nucleated red blood cells (NRBC<\/jats:styled-content>) were microscopically reviewed (n=102).<\/jats:p><\/jats:sec>Results<\/jats:title>The within\u2010run and between\u2010day coefficient of variations (CV<\/jats:styled-content>%) of XN<\/jats:styled-content> 3000 for hemoglobin, RBC<\/jats:styled-content>, MCV<\/jats:styled-content>, WBC<\/jats:styled-content>, and platelets were lower than 5% and for WBC<\/jats:styled-content> differentials lower than 10% except monocytes which was 15.6% at low level. The precision results of DxH 800 were also lower than 5.0% except platelets (9.5%) and monocytes (45%) at low level. The comparison of analyzers revealed good agreement (R<\/jats:italic>>.86), except monocytes and basophils. The flagging sensitivities of XN<\/jats:styled-content> 3000 were higher for IG<\/jats:styled-content>s, blasts, and AL<\/jats:styled-content>s than those of DxH 800 and almost similar for NRBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The XN<\/jats:styled-content> 3000 and DxH 800 are accurate, highly precise systems and can be used effectively in high\u2010volume laboratories. The flagging sensitivity of XN<\/jats:styled-content> 3000 was higher in detecting blasts, IG<\/jats:styled-content>s, and AL<\/jats:styled-content>s than that of DxH 800. The detection of abnormal cells with high sensitivity may improve laboratory workflow with a reduced slide review and accelerated turnaround time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12717","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T04:16:55Z","timestamp":1507177015000},"page":"633-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of performance and abnormal cell flagging of two automated hematology analyzers: Sysmex XN<\/scp> 3000 and Beckman Coulter DxH 800"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2577-9263","authenticated-orcid":false,"given":"S.","family":"Genc","sequence":"first","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Biochemistry Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Dervisoglu","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Biochemistry Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Erdem","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Hematology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Arslan","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Hematology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Aktan","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Hematology Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Omer","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Department of Biochemistry Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/TVGKD5TVB7W9HHC7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01257.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-0945"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/LMEJRJLI8L5ZCDWP"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200930"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12461"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPE5R4SOQBUULZ"},{"key":"e_1_2_7_9_1","volume-title":"Reference Leucocyte (Wbc) Differential Count (Proportional) and Evaluation of Instrumental Methods: CLSI Document H20\u2010A2 Approved Standard","author":"Clinical and Laboratory Standard Institute (CLSI)","year":"2007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.05019"},{"key":"e_1_2_7_11_1","volume-title":"Preliminary Evaluation of Quantitative Clinical Laboratory Procedures; 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