{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:28:36Z","timestamp":1773685716013,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The lymphocyte positional parameters included in Sysmex XN<\/jats:styled-content> have been suggested as useful means to differentiate lymphoproliferative disorders (LPD<\/jats:styled-content>), mononucleosis syndrome (MNS<\/jats:styled-content>) and other lymphocytoses.<\/jats:p><\/jats:sec>Methods<\/jats:title>We evaluated Sysmex XN<\/jats:styled-content> analysers, which supply 6 lymphocyte positional parameters that can be measured in the WDF<\/jats:styled-content> scattergram: LY<\/jats:styled-content>\u2010X, LY<\/jats:styled-content>\u2010Y, LY<\/jats:styled-content>\u2010Z, LY<\/jats:styled-content>\u2010WX<\/jats:styled-content>, LY<\/jats:styled-content>\u2010WY<\/jats:styled-content> and LY<\/jats:styled-content>\u2010WZ<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>We collected 301 samples from normal controls, polyclonal lymphocytosis, MNS<\/jats:styled-content> and LPD<\/jats:styled-content>. MNS<\/jats:styled-content> and monoclonal expansion of T granular lymphocyte (T\u2010GL<\/jats:styled-content>) diagnostic groups accumulated higher numbers of significant differences in the mean values in comparison with the other groups. We propose a new algorithm that can differentiate T\u2010GL<\/jats:styled-content> cases from other diagnostic groups with an SE<\/jats:styled-content> of 67.5%, an SP<\/jats:styled-content> of 98.2%, a PPV<\/jats:styled-content> of 87.1% and an NPV<\/jats:styled-content> of 94.3%. Another algorithm showed its efficiency to differentiate MNS<\/jats:styled-content> cases from other diagnostic groups with an SE<\/jats:styled-content> of 63.6%, an SP<\/jats:styled-content> of 97.5%, a PPV<\/jats:styled-content> of 70.0% and an NPV<\/jats:styled-content> of 96.7%. In 38.5% of all cases, the analyser did not generate any morphologic flag. Abnormal results in lymphocyte positional parameters were useful to detect 72.5% of these samples.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The lymphocyte positional parameters provided by Sysmex XN<\/jats:styled-content> analysers are useful to differentiate expansions of T\u2010GL<\/jats:styled-content>s from other LPD<\/jats:styled-content> and to differentiate MNS<\/jats:styled-content> cases from other diagnostic groups. In addition, these parameters are very useful for detecting changes in the lymphocytes that make it necessary to review blood smears in samples without morphological flagging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12726","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T08:26:34Z","timestamp":1504513594000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Usefulness of the lymphocyte positional parameters in the Sysmex XN<\/scp> haematology analyser in lymphoproliferative disorders and mononucleosis syndrome"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-6587","authenticated-orcid":false,"given":"J. R.","family":"Furundarena","sequence":"first","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Uranga","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Sainz","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Uresandi","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Argoitia","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Araiz","sequence":"additional","affiliation":[{"name":"Hematology Laboratory Donostia Unibertsitate Ospitalea Donostia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2009.01194.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2010.01247.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12261"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.10.73"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00748.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.012"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2011.680"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21938"},{"key":"e_1_2_5_10_1","unstructured":"Teixid\u00f3M G\u00f3mezArbon\u00e9s J GallartMA.Par\u00e1metros de investigaci\u00f3n avanzada de serie blanca de Sysmex\u2010XN y s\u00edndrome mononucle\u00f3sico. LVIII Congreso Nacional de la Sociedad Espa\u00f1ola de Hematolog\u00eda y Hemoterapia Santiago de Compostela 2016. 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