{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:22:28Z","timestamp":1779250948939,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004787","name":"The Research Council","doi-asserted-by":"publisher","award":["RC\/MED\/HAEM\/14\/02"],"award-info":[{"award-number":["RC\/MED\/HAEM\/14\/02"]}],"id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004787","name":"The Research Council","doi-asserted-by":"publisher","award":["RC\/MED\/HAEM\/14\/02"],"award-info":[{"award-number":["RC\/MED\/HAEM\/14\/02"]}],"id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Bleeding assessment tools have evolved in the last decade to standardize the assessment of the severity of bleeding symptom in a consistent way. In 2010, the International Society on Thrombosis and Hemostasis\u2010Bleeding Assessment Tool (ISTH<\/jats:styled-content>\u2010BAT<\/jats:styled-content>) was developed and validated.<\/jats:p><\/jats:sec>Aims<\/jats:title>Our aim was to administer ISTH<\/jats:styled-content>\u2010BAT<\/jats:styled-content> questionnaire to the Omani patients with type 1 VWD<\/jats:styled-content> and obtain the bleeding score (BS<\/jats:styled-content>). We also studied the severity of their bleeding symptoms and correlated it with the BS<\/jats:styled-content> as well as with the laboratory parameters.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010eight type I VWD<\/jats:styled-content> index cases and 52 normal subjects were interviewed and the ISTH<\/jats:styled-content>\u2010BAT<\/jats:styled-content> questionnaire administered. The BS<\/jats:styled-content> was calculated based on a history of bleeding symptoms from 12 different sites according to the standard ISTH<\/jats:styled-content>\u2010BAT<\/jats:styled-content> questionnaire. Laboratory parameters were obtained from patient's medical records.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean age of this cohort was 27\u00a0years (range, 6\u201049) with 60% being females. The median time to administer this questionnaire was 10\u00a0minutes with an interquartile range (IQR<\/jats:styled-content>) from 8 to 17\u00a0minutes. Overall, the median BS<\/jats:styled-content> was 7 (IQR<\/jats:styled-content>; 2,11) although individual scores ranged between 0 and 36. The BS<\/jats:styled-content> was negatively correlated with VWF<\/jats:styled-content>: Ag, VWF<\/jats:styled-content>: RC<\/jats:styled-content>o, and VWF<\/jats:styled-content>: CB<\/jats:styled-content> and the Spearman's correlation coefficient \u201crho\u201d was, respectively, \u20100.15, \u20100.08, and \u20100.22.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The ISTH<\/jats:styled-content>\u2010BAT BS<\/jats:styled-content> is designed to reflect the severity of bleeding. Our results demonstrate the inherent variability of this bleeding pattern. We also found that the ISTH<\/jats:styled-content>\u2010BAT BS<\/jats:styled-content> significantly correlated with VWF<\/jats:styled-content>: Ag and VWF<\/jats:styled-content>: CB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12761","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T12:02:36Z","timestamp":1510142556000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Bleeding score in Type 1 von Willebrand disease patients using the ISTH<\/scp>\u2010BAT<\/scp> questionnaire"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-0611","authenticated-orcid":false,"given":"A.","family":"Pathare","sequence":"first","affiliation":[{"name":"Department of Haematology, College of Medicine & Health Sciences Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Al Omrani","sequence":"additional","affiliation":[{"name":"Department of Haematology, College of Medicine & Health Sciences Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Al Hajri","sequence":"additional","affiliation":[{"name":"Department of Haematology, College of Medicine & Health Sciences Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Al Obaidani","sequence":"additional","affiliation":[{"name":"Department of Haematology, College of Medicine & Health Sciences Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Al Balushi","sequence":"additional","affiliation":[{"name":"Department of Haematology, College of Medicine & Health Sciences Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Al Falahi","sequence":"additional","affiliation":[{"name":"Department of Haematology, College of Medicine & Health Sciences Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00894.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2013.051"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13064"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12248"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01581.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2892"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01245.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12747"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12799"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00975.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.04.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03182.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.152.3798226"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12332"},{"key":"e_1_2_8_18_1","first-page":"301","article-title":"Cleves","volume":"2","author":"Mario A","year":"2002","journal-title":"From the help desk: Comparing areas under receiver operating characteristic curves from two or more probit or logit models, The Stata Journal"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12503"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04775.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04105.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03796.x"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:51:35Z","timestamp":1695509495000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/ijlh.12761"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12761","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}