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A proportion of activated factor VII<\/jats:styled-content> (VII<\/jats:styled-content>a) circulates in complex with antithrombin (VII<\/jats:styled-content>aAT<\/jats:styled-content>). Our primary objective was to assess the effects of postprandial lipemia on circulating VII<\/jats:styled-content>aAT<\/jats:styled-content>, procoagulant phospholipid (PPL<\/jats:styled-content>) activity, and thrombin generation.<\/jats:p><\/jats:sec>Methods<\/jats:title>Plasma samples from postmyocardial infarction patients (n\u00a0=\u00a040) and controls (n\u00a0=\u00a039) were taken before and at 3 and 6\u00a0hours during a standardized oral fat tolerance test (OFTT<\/jats:styled-content>). Fasting PPL<\/jats:styled-content> activity measurements were also made in a second cohort of 108 postinfarction patients and 109 controls. VII<\/jats:styled-content>aAT<\/jats:styled-content> was analyzed with the Asserachrom VII<\/jats:styled-content>aAT ELISA<\/jats:styled-content>, PPL<\/jats:styled-content> activity with the STA<\/jats:styled-content>\u2010Procoag\u2010PPL<\/jats:styled-content> kit, and thrombin generation with calibrated automated thrombogram with PRP<\/jats:styled-content>\u2010Reagent as trigger (all Diagnostica Stago products).<\/jats:p><\/jats:sec>Results<\/jats:title>Postprandially, VII<\/jats:styled-content>aAT<\/jats:styled-content> increased in all samples without significant case\u2010control differences in the overall response during the OFTT<\/jats:styled-content>. Thrombin generation measures peak height and velocity, and PPL<\/jats:styled-content> activity, were marginally affected by the test meal in the controls. Levels of all patient baseline measures were significantly different from controls, indicating a more hypercoagulable state, and these differences were maintained throughout the OFTT<\/jats:styled-content>. Fasting samples from cases showed higher PPL<\/jats:styled-content> activity than control samples.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Viewing VII<\/jats:styled-content>aAT<\/jats:styled-content> quantitation as a surrogate for TF<\/jats:styled-content> activity measurement, postprandial increase in VII<\/jats:styled-content>aAT<\/jats:styled-content> may reflect a mechanism that adds to the cardiovascular risk associated with postprandial lipemia. On the other hand, the impact of postprandial lipemia on PPL<\/jats:styled-content> activity and thrombin generation seems to be minor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12773","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:49:11Z","timestamp":1516636151000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["VII<\/scp>aAT<\/scp> complexes, procoagulant phospholipids, and thrombin generation during postprandial lipemia"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-4935","authenticated-orcid":false,"given":"A.","family":"Silveira","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Unit Department of Medicine Solna and Center for Molecular Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carlo","sequence":"additional","affiliation":[{"name":"Diagnostica Stago Gennevilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Adam","sequence":"additional","affiliation":[{"name":"Diagnostica Stago Gennevilliers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"McLeod","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Unit Department of Medicine Solna and Center for Molecular Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lundman","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Division of Cardiovascular Medicine Danderyd University Hospital, Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Boquist","sequence":"additional","affiliation":[{"name":"Department of Cardiology Karolinska University Hospital Solna Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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