{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:48:16Z","timestamp":1791920896987,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>The bone marrow biopsy (BMB<\/jats:styled-content>) is a diagnostic and staging tool in lymphoma that remains practically useful and relevant in resource\u2010constrained settings, despite restricted applications in international staging guidelines, which favour less invasive nuclear medicine techniques.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective laboratory data review of BMB<\/jats:styled-content>s in adult lymphoma patients from 2005 to 2010 to determine subtypes, rates of bone marrow involvement (BMI<\/jats:styled-content>), human immunodeficiency virus (HIV<\/jats:styled-content>) seroprevalence and CD<\/jats:styled-content>4 counts, trephine length and additional findings.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 1215 BMB<\/jats:styled-content>s reported in lymphoma included 759 newly diagnosed patients, with BMI<\/jats:styled-content> in 43.6% of non\u2010Hodgkin lymphoma (NHL<\/jats:styled-content>) overall, 28.9% of high\u2010grade B subtypes and 35.7% of Hodgkin lymphoma (HL<\/jats:styled-content>). HIV<\/jats:styled-content> seroprevalence was 38.8%, 53.0% and 33.9% in the 3 respective groups. There was a statistical association between BMI<\/jats:styled-content> and HIV<\/jats:styled-content> seropositivity in Burkitt lymphoma and HL<\/jats:styled-content>, and BMI<\/jats:styled-content> and CD<\/jats:styled-content>4 count in HIV<\/jats:styled-content>\u2010related HL<\/jats:styled-content>. Over 10% (n\u00a0=\u00a079) of new lymphoma cases were diagnosed by BMB<\/jats:styled-content> with ancillary tests. Occasional histological discordance and transformation were reported in NHL<\/jats:styled-content>. Focal\/unilateral BMI<\/jats:styled-content> was uncommon. Bilateral BMB<\/jats:styled-content> and biopsy length exceeding 26\u00a0mm did not improve BMI<\/jats:styled-content> detection.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In the South African public sector, high HIV<\/jats:styled-content> prevalence leads to a different lymphoma pathology profile from the developed world. High BMI<\/jats:styled-content> rates are encountered. Here, and in similar resource\u2010constrained settings, international lymphoma staging guidelines can be logistically challenging and unaffordable. BMB<\/jats:styled-content> remains useful in the staging and diagnosis of lymphoma. Unilateral sampling with a processed trephine length of at least 26\u00a0mm is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12782","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T07:46:36Z","timestamp":1518248796000},"page":"276-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The utility of bone marrow sampling in the diagnosis and staging of lymphoma in South Africa"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-9874","authenticated-orcid":false,"given":"L.","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Haematology Red Cross War Memorial Children's Hospital Laboratory National Health Laboratory Service Cape Town South Africa"},{"name":"Division of Haematology Department of Pathology University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Opie","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Pathology University of Cape Town Cape Town South Africa"},{"name":"Department of Haematology Groote Schuur Hospital Laboratory National Health Laboratory Service Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,10]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S","year":"2008"},{"key":"e_1_2_7_3_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S","year":"2017"},{"key":"e_1_2_7_4_1","unstructured":"FerlayJ SoerjomataramI ErvikM et\u00a0al.GLOBOCAN 2012 v1.0 cancer incidence and mortality worldwide:IARCCancerBase no. 11 [internet]. 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