{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:48:57Z","timestamp":1774061337821,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Malaria is a life\u2010threatening infectious disease, which has been for long confined to specific endemic areas. Nevertheless, the recent increase in immigration flows from endemic regions and imported cases has reemphasized many diagnostic challenges in Western countries, thus paving the way to introduce rapid and accurate strategies for screening subjects with suspected Malaria infection. Therefore, the aim of this article was to describe our recent experience with Sysmex <jats:styled-content style=\"fixed-case\">XN<\/jats:styled-content>\u2010module for rapid screening of subjects with suspected Malaria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients admitted to the Emergency Department (Papa Giovanni <jats:styled-content style=\"fixed-case\">XXIII<\/jats:styled-content> Hospital Bergamo, Italy) with a clinical suspicion of Malaria infection were evaluated, along with 1047 control samples. The analysis of peripheral blood was performed with <jats:styled-content style=\"fixed-case\">XN<\/jats:styled-content>\u2010module, and results were then compared to optical microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients were positive to <jats:italic>Plasmodim falciparum<\/jats:italic>, 3 to <jats:italic>Plasmodim vivax<\/jats:italic>, one to <jats:italic>Plasmodim ovale,<\/jats:italic> and one to <jats:italic>Plasmodim malarie<\/jats:italic>. Characteristic abnormalities could be observed in both white blood cell differential (<jats:styled-content style=\"fixed-case\">WDF<\/jats:styled-content>) and white cell nucleated (<jats:styled-content style=\"fixed-case\">WNR<\/jats:styled-content>) scattergrams (sensitivity 0.64 and specificity 1.0) in 9 samples with parasites at gametocyte or schizos stage irrespective of Plasmodium species and parasitic index, while characteristic scattergram abnormalities could not be seen in the 5 samples containing only parasites at the trophozoites stage. In these cases, specific variations of some cell population data (<jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>) could be recorded (sensitivity 1.00 and specificity 0.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The peculiar abnormalities observed in <jats:styled-content style=\"fixed-case\">CPD<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">WDF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">WNR<\/jats:styled-content>\u2010scattergrams may raise a definite suspicion of Malaria infection. Further studies should then be planned for validating these preliminary findings and assessing whether these specific abnormalities may be incorporated in rapid and inexpensive Malaria diagnostic algorithms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12790","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:17:52Z","timestamp":1519244272000},"page":"326-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Abnormal scattergrams and cell population data generated by fully automated hematological analyzers: New tools for screening malaria infection?"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-0727","authenticated-orcid":false,"given":"S.","family":"Buoro","sequence":"first","affiliation":[{"name":"Clinical Chemistry Laboratory Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Manenti","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Seghezzi","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Moioli","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bagorria","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Callegaro","sequence":"additional","affiliation":[{"name":"Microbiology and Virology Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ottomano","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory Synlab  Castenedolo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lippi","sequence":"additional","affiliation":[{"name":"Section of Clinical Biochemistry University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.World Malaria Report 2016.Geneva Switzerland:World Health Organization;2016. Licence: CC BY\u2010NC\u2010SA 3.0 IGO"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-3-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1999.00220.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics7030054"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Automated haematology analysis to diagnose malaria","volume":"30","author":"Campuzano\u2010Zuluaga G","year":"2010","journal-title":"Malar J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5958\/2394-6792.2016.00122.8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/0PL3C674M39D6GEN"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12145"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0464"},{"key":"e_1_2_7_11_1","first-page":"82","article-title":"Comparative evaluation of two flow cytometric analysers as diagnostic tools for the automated detection of malaria","volume":"44","author":"Mohapatra S","year":"2014","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0987-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.09-0560"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.1999.00243.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00426.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9286392","article-title":"Laboratory diagnosis of malaria: comparison of manual and automated diagnostic tests","author":"Mukry SN","year":"2017","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200930"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.07.009"},{"key":"e_1_2_7_19_1","first-page":"256","article-title":"Evaluation of reference intervals for complete blood count on Sysmex XN 9000","volume":"39","author":"Buoro S","year":"2015","journal-title":"Biochim Clin"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.05019"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12720"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12526"}],"updated-by":[{"DOI":"10.1111\/ijlh.13077","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000}}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12790","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:37:44Z","timestamp":1695476264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/ijlh.12790"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12790","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/ijlh.13077","asserted-by":"object"}]},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}