{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T16:36:01Z","timestamp":1776616561907,"version":"3.51.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Richter Gedeon Centen\u00e1riumi Alap\u00edtv\u00e1ny","award":["no number"],"award-info":[{"award-number":["no number"]}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thrombogenesis plays an important role in today's morbidity and mortality. Antithrombotics are among the most frequently prescribed drugs. Thorough knowledge of platelet function is needed for optimal clinical care. Platelet adhesion is a separate subprocess of platelet thrombus formation; still, no well\u2010standardized technique for the isolated measurement of platelet adhesion exists. Impedimetry is one of the most reliable, state\u2010of\u2010art techniques to analyze cell adhesion, proliferation, viability, and cytotoxicity. We propose impedimetry as a feasible novel method for the isolated measurement of 2 significant platelet functions: adhesion and spreading.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Laboratory reference platelet agonists (epinephrine, <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>, and collagen) were applied to characterize platelet functions by impedimetry using the <jats:styled-content style=\"fixed-case\">xCELL<\/jats:styled-content>igence <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> system. Platelet samples were obtained from 20 healthy patients under no drug therapy. Standard laboratory parameters and clinical patient history were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Epinephrine and <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> increased platelet adhesion in a concentration\u2010dependent manner, while collagen tended to have a negative effect. Serum sodium and calcium levels and age had a negative correlation with platelet adhesion induced by epinephrine and <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>, while increased immunoreactivity connected with allergic diseases was associated with increased platelet adhesion induced by epinephrine and <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> increased platelet spreading in a concentration\u2010dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Impedimetry proved to be a useful and sensitive method for the qualitative and quantitated measurement of platelet adhesion, even differentiating between subgroups of a healthy population. This novel technique is offered as an important method in the further investigation of platelet function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12799","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T10:32:39Z","timestamp":1520418759000},"page":"372-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet impedance adhesiometry: A novel technique for the measurement of platelet adhesion and spreading"],"prefix":"10.1111","volume":"40","author":[{"given":"L.","family":"Polg\u00e1r","sequence":"first","affiliation":[{"name":"Department of Genetics, Cell\u2010 and Immunobiology Semmelweis University  Budapest Hungary"},{"name":"Heart and Vascular Center Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"So\u00f3s","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center Semmelweis 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