{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:20:02Z","timestamp":1788009602974,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Guillain\u2010Barr\u00e9 syndrome (\n GBS<\/jats:styled-content>\n ) is an inflammatory demyelinating autoimmune disease, associated with blood\u2010nerve barrier breakdown, inflammatory cells infiltration, and cytokine leakage in the peripheral nervous system. Currently, it has been revealed that monocytes play key roles in the inflammatory response. Therefore, we aimed to assess the correlation between monocyte count and\n GBS<\/jats:styled-content>\n in this study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective study was conducted in 114 patients with\n GBS<\/jats:styled-content>\n and 120 age\u2010 and gender\u2010matched individuals.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Absolute monocyte count in patients with\n GBS<\/jats:styled-content>\n was higher than that in healthy controls (0.61\u00a0\u00b1\u00a00.24 vs 0.41\u00a0\u00b1\u00a00.10;\n P<\/jats:italic>\n \u00a0\u200a<\u00a0.001). Interestingly, monocyte count had significant positive correlations with\n CRP<\/jats:styled-content>\n ,\n ESR<\/jats:styled-content>\n , and disease severity of\n GBS<\/jats:styled-content>\n (\n r<\/jats:italic>\n \u00a0=\u00a0.244,\n P<\/jats:italic>\n \u00a0=\u00a0.009;\n r<\/jats:italic>\n \u00a0=\u00a0.269,\n P<\/jats:italic>\n \u00a0=\u00a0.004;\n r<\/jats:italic>\n \u00a0=\u00a0.322,\n P<\/jats:italic>\n \u00a0<\u00a0.001). A cutoff value of 0.515 for monocyte count was observed in patients with\n GBS<\/jats:styled-content>\n (areas under the curve\u00a0=\u00a00.808, 95% confidence interval\u00a0=\u00a00.749\u20100.868,\n P<\/jats:italic>\n \u00a0\u200a<\u00a0.001). Meanwhile, absolute monocyte count was independently associated with\n GBS<\/jats:styled-content>\n in logistic regression analysis (odds ratio\u00a0=\u00a02.291, 95% confidence interval\u00a0=\u00a03.557\u201027.493,\n P<\/jats:italic>\n \u00a0<\u00a0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our findings demonstrated that elevated monocyte count is independently associated with\n GBS<\/jats:styled-content>\n patients, and suggested monocyte count is positively associated with disease severity of\n GBS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijlh.12845","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T11:12:20Z","timestamp":1525259540000},"page":"488-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Can we assess severity of Guillain\u2010Barr\u00e9 syndrome using absolute monocyte count?"],"prefix":"10.1111","volume":"40","author":[{"given":"X.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-3246","authenticated-orcid":false,"given":"W.","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67665-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22514"},{"key":"e_1_2_7_4_1","first-page":"165","article-title":"Guillain\u2010Barre syndrome: a common neurological entity with myriad 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