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A proper evaluation of persistent eosinophilia involves correlation of clinical history, laboratory data, cellular morphology, and ancillary testing. Knowledge of appropriate ancillary testing is necessary for a timely diagnosis. We present a review of the literature regarding eosinophilia, including the 2016 World Health Organization (WHO) update of WHO\u2010defined eosinophilic disorders. We also present a review of eosinophilia in a case\u2010based format including guidelines for evaluation of both routine and challenging cases. The purpose of this guideline is not to provide an in\u2010depth discussion of each diagnosis, but rather a practical method that all pathologists can utilize to investigate eosinophilia.<\/jats:p>","DOI":"10.1111\/ijlh.12955","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T11:21:03Z","timestamp":1543576863000},"page":"153-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["How I investigate Eosinophilia"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-7858","authenticated-orcid":false,"given":"Rebecca L.","family":"Larsen","sequence":"first","affiliation":[{"name":"Medical College of Georgia Augusta University  Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha M.","family":"Savage","sequence":"additional","affiliation":[{"name":"Medical College of Georgia Augusta University  Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105712"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.07.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.01.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24880"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_8_8_1","first-page":"54","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Bain BJ","year":"2017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197501000-00001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","article-title":"The idiopathic hypereosinophilic syndrome","author":"Weller PF","year":"1994","journal-title":"Blood"},{"key":"e_1_2_8_11_1","unstructured":"College of American Pathologists. 2018 Hematology and Clinical Microscopy Glossary.http:\/\/www.cap.org\/ShowProperty?nodePath=\/UCMCon\/Contribution%20Folders\/WebContent\/pdf\/hematology-glossary.pdf. 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